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Pathogenicity studies of the Brazilian variant strain (BR) of infectious bronchitis virus

Grant number: 13/02058-6
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2013
Effective date (End): February 28, 2015
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Principal Investigator:Clarice Weis Arns
Grantee:Leonardo Cardia Caserta
Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Recent studies identified variants of the Infectious bronchitis vírus (IBV) exclusives from Brazil (BR), which genotype is not related to the Massachussets serotype. In Brazil, alive vaccines for IBV are only allowed if belonging to this serotype, what suggests an inefficient protection against brazilian variants. Due to the lack of studies focusing the pathogenicity of the BR variant of IBV, the knowledge of its effects becomes necessary, elucidating clinical signs, macroscopic and microscopic lesions, besides the immunity against this virus. This study aims to analyse the pathogenicity and tropism of the BR variant of IBV for poultries through a in vivo experiment, using specific pathogen free (SPF) birds. The observation of clinical signs, besides serology, histopathology and real time RT-PCR of the organs samples will be the techniques chosen to assess the immune response, lesions and to quantificate the viral RNA, defining then the tropism of this variant.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CASERTA, Leonardo Cardia. Pathogenicity studies of the brazilian variant strain (BR) of infectious bronchitis virus. 2015. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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