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Effects of aerobic physical training on leukocytes activation in an experimental model of intra and extra-pulmonary acute lung injury

Grant number: 12/25435-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2013
Effective date (End): April 30, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Rodolfo de Paula Vieira
Grantee:Larissa Hilario Dulley
Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil


Acute respiratory distress syndrome (ARDS) is a term used to indicate the respiratory insufficiency following the inflammatory response resulting in alterations in the alveoli-capillary permeability, pulmonary edema, and hypoxemia to high oxygen rates, added of intense pulmonary and systemic inflammation. The anti-inflammatory effects of aerobic physical activity on different pulmonary diseases have been extensively investigated. Therefore, since the low and moderate-intensity aerobic training, performed 3 to 5x/week, 60 minutes per session presents beneficial effects on the immune system, with direct repercussions on the lungs in different pulmonary diseases, we will evaluate the effects of five weeks of treadmill aerobic physical training, at 60% of maximal intensity, 5x/week, 60 minutes per session on the following parameters: pulmonary inflammation, cytokines levels in bronchoalveolar lavage and the expression of toll-like receptors 2, 4, 7 and 9 by pulmonary leukocytes in a model of intra and extra-pulmonary acute lung injury induced by LPS. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIGONATO-OLIVEIRA, NICOLE CRISTINE; MACKENZIE, BREANNE; LACERDA BACHI, ANDRE LUIS; OLIVEIRA-JUNIOR, MANOEL CARNEIRO; SANTOS-DIAS, ALANA; RODRIGUES BRANDAO-RANGEL, MAYSA ALVES; DELLE, HUMBERTO; COSTA-GUIMARAES, TAMARA; DAMACENO-RODRIGUES, NILSA REGINA; DULLEY, LARISSA HILARIO; et al. Aerobic exercise inhibits acute lung injury: from mouse to human evidence Exercise reduced lung injury markers in mouse and in cells. EXERCISE IMMUNOLOGY REVIEW, v. 24, p. 48-56, . (12/25435-7, 12/15165-2, 14/23196-0, 12/24880-7)

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