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Analysis of the patterns of antibiotic sensitivity in pioneer strains of streptococci from the oral cavity

Grant number: 13/06820-0
Support Opportunities:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): July 01, 2013
Effective date (End): July 31, 2013
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Renata de Oliveira Mattos Graner
Grantee:Thaís Harder de Palma
Supervisor: Margaret J. Duncan
Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil
Research place: Forsyth Institute, United States  
Associated to the scholarship:11/09761-9 - Analysis of patterns of antibiotic sensitivity in pioneer strains of Streptococcus of the human oral cavity, BP.IC


This project aims to complement the Scientific Initiation Research Project entitled "Analysis of the patterns of antibiotic sensitivity in pioneer strains of Streptococci from the oral cavity". In this project, we identified in the oral cavity of 2 to 16-month-old children, a high prevalence of strains of Streptococcus salivarius, which were resistant to several classes of antibiotics (beta-lactams, tetracyclines, macrolides, and aminoglycosides). Among the 21 children studied, a total of 79 S. salivarius strains were resistant to one or more antibiotics. Among these, 26 were resistant to two or more classes of antibiotics indicating a multidrug resistance phenotype. The objective of this BEPE project is to identify genes involved in the phenotype of resistance to multiple antibiotics in the strains of Streptococcus salivarius isolated from the oral cavity of children who were 2-16 months of age. This internship will be performed at The Forsyth Institute under the supervision of Dr. Margaret J. Duncan, Department of Microbiology, The Forsyth Institute, Cambridge, MA, USA in July 2013. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PALMA, THAIS H.; HARTH-CHU, ERIKA N.; SCOTT, JODIE; STIPP, RAFAEL N.; BOISVERT, HEIKE; SALOMAO, MARIANA F.; THEOBALDO, JESSICA D.; POSSOBON, ROSANA F.; NASCIMENTO, LEANDRO C.; MCCAFFERTY, JONATHAN W.; et al. Oral cavities of healthy infants harbour high proportions of Streptococcus salivarius strains with phenotypic and genotypic resistance to multiple classes of antibiotics. Journal of Medical Microbiology, v. 65, n. 12, p. 1456-1464, . (13/06820-0, 15/12940-3, 12/51832-3, 09/50547-0, 10/06786-8, 11/09761-9, 10/06785-1)

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