Despite the high regenerative capacity of bone tissue, the biologic process may fail or be limited by factors such as the size of the defect. Bone remodeling is a process that occurs in localized bone degradation, followed by deposition in equal quantity of bone material in the same location. Currently, stem cell therapy has shown promise in the treatment of experimental bone repair. In this sense, tissue engineering has emerged as a multidisciplinary field that aims to regenerate tissues and restore organ function by combining living cells with a synthetic or natural sacaffold to produce a three-dimensional living tissue that is functionally structurally and mechanically the same as the original tissue. The possibility of using a Fibrin Sealant, whose polymerizing factor is derived from snake venom, opens an important medical-surgical option. The advantages to conventional sealants available , not using human blood in their composition, the possibility of formulating customized to the need of surgery, taking into account the clotting time, as well as controlling the degradation time of Sealant . The possibility of using cells suspended in fibrin sealants, instead of commonly used solid scaffolds, allows rapid stabilization of these cells in suspension. This project aims to evaluate the influence of Fibrin Sealant derived from snake venom on mesenchymal stem cells (MSCs) non-differentiated and pre-differentiated in the repair of bone defects in rat femurs. Considering that the use of fibrin sealant can be applied as sacaffold for biological MSCs, so we can create alternative therapies in bone repair.
News published in Agência FAPESP Newsletter about the scholarship: