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Evaluation of stability, cutaneous penetration and antioxidant activity of quercetin encapsulated in nanostructured lipid carriers of shea butter and coconut oil

Grant number: 13/00844-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2013
Effective date (End): January 31, 2014
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Priscyla Daniely Marcato Gaspari
Grantee:Jéssica Rodrigues Dias
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Oxidative stress generated by degradation products of metabolism and cellular respiration, as well as substances found in food, is among the causes of lipid peroxidation of skin layers that contribute to skin aging. Thus, there is a growing application of antioxidant compounds, in order to delay the senescence process. Quercetin is a flavonoid found in plants species, which has antioxidant properties, anti-inflammatory and photoprotective, however exhibits photosensitivity, low chemical stability, and insolubility in water. These properties indicate that quercetin needs to be incorporated in particulate systems in order to become effective in its clinical application. Thus, the use of nanostructured lipid carriers (NLC) has been the preferential choice for drug delivery system for topical administration due to properties associated with this system, which contribute to maintaining the chemical stability and photostability of the drug, enhance molecules skin permeation and prolong the drug time in the skin. In this project, CLN will be developed for quercetin incorporation, composed of a natural lipids mixture of shea butter and coconut oil, that have emollient, anti-inflammatory, and antimicrobial properties, which support the choice of these lipids in order to add their properties with those of quercetin. CLNs will be characterized by size, surface charge, morphology, and stability. Furthermore, studies of quercetin stability, in vitro skin permeation, antioxidant effects, and determination of encapsulation efficiency will be carried out, in order to develop new strategies for antioxidant application in topical formulations using natural materials. Thus, it is expected that the CLNs will be able to carry quercetin through progressive release, leading to increase dermal penetration and greater stability of quercetin in cosmetic formulations. (AU)

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Filed patent(s) as a result of this research project

FORMULAÇÃO DE CARREADORES LIPIDICOS NANOESTRUTURADOS E USO DA MESMA BR1020140264990 - Universidade de São Paulo (USP) . Jéssica Rodrigues Dias ; Maria Perpétua Freire de Morais Del Lama ; Patricia Maria Berardo Çonçalves M. Campos ; Priscyla Daniley Marcato Gaspar ; Rose Mary Zumstein Georgetto Naal ; Thas Priscilla Pivetta - October 2014, 23