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Development and characterization of liquid crystalline systems for incorporation of trans-resveratrol: in vitro cutaneous permeation tests and in vivo assessment of the effectiveness

Grant number: 12/16956-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2013
Effective date (End): September 30, 2014
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Marlus Chorilli
Grantee:Andressa Terumi Fujimura
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


The daily exposure of the skin to ultraviolet radiation can cause direct damage to DNA and cause the proliferation of reactive oxygen species (ROS), which leads to an imbalance between free radicals and antioxidant enzymes in the epidermis, such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). This imbalance leads to a state of oxidative stress and consequently to photoaging, which can be delayed and even treated by the use of products with antioxidant properties. Researches have shown many beneficial effects of trans-resveratrol (RES) to human health, including its antioxidant and anti-inflamatory actions. It can be an important ally on prevention and treatment of cutaneous desorders like cutaneous aging, hyperpigmentation and cacinogenesis. However, some of their physicochemical properties, such as limited aqueous solubility, make their effectiveness on therapeutic cutaneous more difficult since it has low penetration into the skin. Thus, the use of nanostructured delivery systems for cutaneous administration of the RES, such as liquid-crystalline systems (LCS) would be extremely viable in order to locate the active ingredient in its site of action, modulating their action and reducing possible side effects, and increasing their penetration through the stratum corneum. The objectives of this work are to develop LCS to incorporate the RES and to characterize them by means of polarized light microscopy, small-angle x-ray scattering (SAXS) and rheology. Release, retention and permeation tests will be performed in vitro using skin of an animal model. Subsequently, the effectiveness will be verified in vivo model of stress oxidative cutaneous induced by UVB radiation.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FUJIMURA, ANDRESSA T.; MARTINEZ, RENATA M.; PINHO-RIBEIRO, FELIPE A.; LOPES DIAS DA SILVA, AMELIA M.; BARACAT, MARCELA M.; GEORGETTI, SANDRA R.; VERRI, JR., WALDICEU A.; CHORILLI, MARLUS; CASAGRANDE, RUBIA. Resveratrol-Loaded Liquid-Crystalline System Inhibits UVB-Induced Skin Inflammation and Oxidative Stress in Mice. Journal of Natural Products, v. 79, n. 5, p. 1329-1338, . (14/24180-0, 12/16956-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FUJIMURA, Andressa Terumi. Desenvolvimento e caracterização de sistemas líquido cristalinos para incorporação do trans-resveratrol: ensaios de permeação cutânea in vitro e avaliação da eficácia in vivo. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.

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