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Genomic, proteomic and metabolomic study of gastrointestinal tissue for patients with type 2 Diabetes mellitus after Roux-en-Y gastric bypass

Grant number: 13/03246-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2013
Effective date (End): March 31, 2017
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal researcher:Dan Linetzky Waitzberg
Grantee:Priscila Sala Kobal
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:11/09612-3 - Changes in gene expression in gastric and intestinal tissue of type 2 Diabetes patients submitted to Roux-en-Y gastric bypass, AP.TEM
Associated scholarship(s):14/07742-5 - Genomic, proteomic and metabolomic study of gastrointestinal tissue for patients with type 2 diabetes mellitus after Roux-en-Y gastric bypass, BE.EP.DD


Type 2 diabetes mellitus (T2DM) is a relevant public health and obesity has been associated as the major risk factor. Roux-en-Y gastric bypass is an effective method to treat severe obesity, and its metabolic benefits lead to early and complete remission of T2DM, even before a considerable weight loss. Experimentally, the anatomical changes induced by RYGB can change genes expression in gastrointestinal tissue related to glucose control determinants to T2DM reversal. However, there aren't clinical studies that prove these findings in humans. Some gastrointestinal hormones already have been studied as possible mediators of glycemic control improvement after metabolic surgery, such as, ghrelin, peptide YY, enteroglucagon and incretins (GLP-1 and GIP). Due to endocrine effects of Roux-en-Y gastric bypass, it is reasonable to believe that other hormones and mechanisms are involved in glycemic homeostasis after surgery. The genomic, proteomic and metabolomics studies of gastrointestinal tissue in T2DM patients after Roux-en-Y gastric bypass can provide a better understanding of the T2DM pathophysiology enabling the study of new therapeutic targets for the treatment of this clinical condition. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SALA, PRISCILA; TORRINHAS, RAQUEL SUSANA; FONSECA, DANIELLE CRISTINA; HEYMSFIELD, STEVEN; GIANNELLA-NETO, DANIEL; WAITZBERG, DAN LINETZKY. Type 2 Diabetes Remission After Roux-en-Y Gastric Bypass: Evidence for Increased Expression of Jejunal Genes Encoding Regenerating Pancreatic Islet-Derived Proteins as a Potential Mechanism. OBESITY SURGERY, v. 27, n. 4, p. 1123-1127, . (13/03246-0, 11/09612-3)
SALA, PRISCILA; BELARMINO, GILIANE; TORRINHAS, RAQUEL S.; MACHADO, NATASHA M.; FONSECA, DANIELLE C.; RAVACCI, GRAZIELA R.; ISHIDA, ROBSON K.; GUARDA, ISMAEL F. M. S.; DE MOURA, EDUARDO G.; SAKAI, PAULO; et al. Gastrointestinal Transcriptomic Response of Metabolic Vitamin B12 Pathways in Roux-en-Y Gastric Bypass. CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, v. 8, . (11/09612-3, 13/03246-0)
SALA, PRISCILA; MATOS DE MIRANDA TORRINHAS, RAQUEL SUSANA; FONSECA, DANIELLE CRISTINA; RAVACCI, GRAZIELA ROSA; WAITZBERG, DAN LINETZKY; GIANNELLA-NETO, DANIEL. Tissue-specific methylation profile in obese patients with type 2 diabetes before and after Roux-en-Y gastric bypass. DIABETOLOGY & METABOLIC SYNDROME, v. 9, . (11/09612-3, 13/03246-0)
SALA, PRISCILA CAMPOS; TORRINHAS, RAQUEL SUSANA; GIANNELLA-NETO, DANIEL; WAITZBERG, DAN LINETZKY. Relationship between gut hormones and glucose homeostasis after bariatric surgery. DIABETOLOGY & METABOLIC SYNDROME, v. 6, . (11/09612-3, 13/03246-0)
FONSECA, DANIELLE CRISTINA; SALA, PRISCILA; SINGER, JOELLE; SINGER, PIERRE; TORRINHAS, RAQUEL SUSANA; WAITZBERG, DAN LINETZKY. Upregulation of Ghrelin Gene Expression in the Excluded Stomach of Obese Women with Type 2 Diabetes After Roux-en-Y Gastric Bypass in the SURMetaGIT Study. OBESITY SURGERY, v. 28, n. 3, p. 877-880, . (11/09612-3, 13/03246-0)
SALA, PRISCILA; BELARMINO, GILIANE; MACHADO, NATASHA MENDONCA; CARDINELLI, CAMILA SIQUEIRA; AL ASSAL, KARINA; SILVA, MARIANE MARQUES; FONSECA, DANIELLE CRISTINA; ISHIDA, ROBSON KIYOSHI; SANTO, MARCO AURELIO; HOURNEAUX DE MOURA, EDUARDO GUIMARAES; et al. The SURMetaGIT study: Design and rationale for a prospective pan-omics examination of the gastrointestinal response to Roux-en-Y gastric bypass surgery. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v. 44, n. 6, p. 1359-1375, . (16/01259-6, 14/05220-1, 15/22820-5, 11/09612-3, 13/03246-0, 13/23355-9, 14/07742-5, 12/23762-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
KOBAL, Priscila Sala. Changes in the gene expression of gastric and intestinal tissues of patients with tpe 2 diabetes mellitus submitted to Roux-en-Y gastric bypass. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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