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Assessment of the effects of maternal exposure to Butyl 4-hydroxybenzoate (butyl paraben) during gestational and lactational periods on reproductive development of Wistar rats offspring

Grant number: 13/00314-5
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): April 01, 2013
Effective date (End): September 30, 2015
Field of knowledge:Health Sciences - Pharmacy - Toxicological Analysis
Principal Investigator:Wilma de Grava Kempinas
Grantee:Marina Trevizan Guerra
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Associated scholarship(s):14/09409-1 - Evaluation of the possible effects of in vitro exposure to butylparaben and di-(2-ethylhexyl) phthalate, alone or in association on steroidogenesis, BE.EP.PD


Several contaminants in the environment have the capacity to interfere with endocrine homeostasis of humans and animals and the exposure to these compounds may induce abnormal development of sex organs. Parabens (alkyl esters of Á-hydroxybenzoic acid) are preservatives widely used in pharmaceutical products, food and beverage industries and cosmetics formulations. Besides antifungal and antibacterial actions, these chemicals have been detected in several human tissues and corporal fluids as urine, blood, milk and mammary tissue. Due contradictory and scarce effects in relation to parabens administration on reproductive system and knowing that exposure to substances present in the environment may contribute to several reproductive dysfunctions, especially if it occurs in critical periods of development (intra-uterine and post-natal periods), a more detailed and comprehensive investigation on the possible effects of paraben administration on reproductive function is necessary. The present project aims to evaluate the toxic effects on genital system of male and female offspring, whose mothers were exposed to butyl 4-hydroxybenzoate (butyl paraben) during gestation and lactation.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUERRA, MARINA T.; SANABRIA, MARCIANA; LEITE, GABRIEL A. A.; BORGES, CIBELE S.; CUCIELO, MAIRA S.; ANSELMO-FRANCI, JANETE A.; FOSTER, W. G.; KEMPINAS, W. G.. Maternal exposure to butyl paraben impairs testicular structure and sperm quality on male rats. ENVIRONMENTAL TOXICOLOGY, v. 32, n. 4, p. 1273-1289, . (13/00314-5)
GUERRA, MARINA TREVIZAN; SANABRIA, MARCIANA; CAGLIARANI, STEPHANNIE VIEIRA; ARAUJO LEITE, GABRIEL ADAN; BORGES, CIBELE DOS SANTOS; KEMPINAS, WILMA DE GRAVA. Long-term effects of in utero and lactational exposure to butyl paraben in female rats. ENVIRONMENTAL TOXICOLOGY, v. 32, n. 3, p. 776-788, . (13/00314-5)

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