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Comparison of two methods of implant surface decontamination on re-osseointegration after ligature induced peri-implantitis. A radiographic, histomorphometric and computerized microtomographic study in dogs.

Grant number: 12/09772-3
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): April 01, 2013
Effective date (End): March 31, 2016
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Arthur Belem Novaes Junior
Grantee:Flávia Adelino Suaid Malheiros
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The ideal treatment for peri-implantitis should promote health around implants, regenerating the lost tissues and leading to the re-osseointegration. Many studies were conducted, but no study showed significant results in obtaining bone re-osseointegration. The present study will compare the computerized microtomographic and the histomorphometric methods in the re-osseointegration analysis. The re-osseointegration will be investigated comparing implants treated with tetracycline hydrochloride or with antimicrobial photodynamic therapy. Firstly, the bilateral mandibular premolars of 8 dogs will be extracted, after eight weeks, four implants will be installed in each hemi-mandible of each animal. Peri-implantitis will be induced by placing 3.0 silk ligatures around the implants bilaterally during 8 weeks. After 16 weeks with peri-implantitis, the implants will be randomly treated with: only tetracycline hydrochloride application (G1); tetracycline hydrochloride associated with bone grafting and membrane (G2); only antimicrobial photodynamic therapy application (G3); antimicrobial photodynamic therapy associated with bone grafting and membrane (G4); bone grafting and membrane only (G5). After 12 weeks the animals will be sacrificed. The re-osseointegration and the other variables will be evaluated clinically, radiographically, histomorphometrically and through the new computerized microtomographic method.

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