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Effects of exercise on knee osteoarthritis induced by transection of the anterior cruciate ligament in rats

Grant number: 12/23929-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2013
Effective date (End): December 31, 2014
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Ana Claudia Muniz Renno
Grantee:Nayara dos Passos Conceição
Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil


Osteoarthritis (OA) is a common cause of functional limitation and its prevalence has increased in recent decades. Thus, the development of therapeutic strategies aimed mitigate the damage and prevent its evolution becomes important for rehabilitation. The realization of the therapeutic exercise of moderate intensity in the clinical treatment of OA is now well known, yet the signaling pathways activated by these resources remain uncertain. The objective of this study is to evaluate the effects of moderate aerobic exercise on the articular cartilage of the knee of rats submitted to an experimental model of osteoarthritis induced by section of the anterior cruciate ligament (ACLT). Will be used 30 Wistar male rats, separated into 3 groups (n = 10): control (C); osteoarthritic (O); osteoarthritic and exercise (OE). Aerobic exercise will be held 2 weeks after surgery on a treadmill (speed of 16 m / min, 50 me, 3 times per week) for 8 weeks. To evaluate and compare the effects of training will be conducted morphological and morphometric cartilage (cellularity, thickness, density and chondrocyte proteoglycan content) and protein expression of IL-1 ². It is hoped that the results of this project will bring significant contribution in elucidating the mechanisms of action triggered by moderate aerobic exercise, thus optimizing the use of the same in the rehabilitation of degenerative disorders. (AU)

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