Grant number: | 12/17416-2 |
Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
Effective date (Start): | April 01, 2013 |
Effective date (End): | August 31, 2016 |
Field of knowledge: | Health Sciences - Physical Education |
Principal Investigator: | Leonardo dos Reis Silveira |
Grantee: | Michel Barbosa de Araújo |
Host Institution: | Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil |
Associated research grant: | 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID |
Associated scholarship(s): | 15/02278-1 - Regulation of mitochondrial function by hypoxia inducible factor (HIF-1) in insulin resistant muscle cells, BE.EP.PD |
Abstract The insulin resistance in skeletal muscle is a characteristic in diabetics people. Although its mechanism is not totaly known, there is correlation between insulin resistance and intracellular lipid content. However, there is consensus that there is a strong correlation between insulin resistance, physical inactivity and high intracellular lipid content. Our proposal is to evaluate the effect of gene expression of HIF1± in mitochondrial biogenesis in uptake and metabolism of glucose, fatty acid, reactive species production and proteolysis. In order to have a positive control, the effect of its inhibition on the variables mentioned in cells resistant to insulin will also be assess . Our hypothesis is that HIF1± may protect against insulin resistance in the muscle improving mitochondrial function. Confirming our hypothesis, the HIF1±, or even pharmacological compounds that are capable of inhibiting expression of this gene may constitute itself important therapeutic targets against of development insulin resistance in muscle tissue. | |
News published in Agência FAPESP Newsletter about the scholarship: | |
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