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REGULATION OF MITOCHONDRIAL FUNCTION AND METABOLISM OF GLUCOSE AND FATTY ACIDS BY FACTOR OF HYPOXIA INDUCIBLE (HIF-1a) MUSCLE CELLS IN INSULIN RESISTANCE

Grant number: 12/17416-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): April 01, 2013
Effective date (End): August 31, 2016
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Leonardo dos Reis Silveira
Grantee:Michel Barbosa de Araújo
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID
Associated scholarship(s):15/02278-1 - Regulation of mitochondrial function by hypoxia inducible factor (HIF-1) in insulin resistant muscle cells, BE.EP.PD

Abstract

The insulin resistance in skeletal muscle is a characteristic in diabetics people. Although its mechanism is not totaly known, there is correlation between insulin resistance and intracellular lipid content. However, there is consensus that there is a strong correlation between insulin resistance, physical inactivity and high intracellular lipid content. Our proposal is to evaluate the effect of gene expression of HIF1± in mitochondrial biogenesis in uptake and metabolism of glucose, fatty acid, reactive species production and proteolysis. In order to have a positive control, the effect of its inhibition on the variables mentioned in cells resistant to insulin will also be assess . Our hypothesis is that HIF1± may protect against insulin resistance in the muscle improving mitochondrial function. Confirming our hypothesis, the HIF1±, or even pharmacological compounds that are capable of inhibiting expression of this gene may constitute itself important therapeutic targets against of development insulin resistance in muscle tissue.

News published in Agência FAPESP Newsletter about the scholarship:
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