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Detection of endocrine disruptors testosterone and estradiol in environmental samples utilizing modified electrodes with graphene, the gold nanoparticles and quantum dots.

Grant number: 12/18339-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2012
Effective date (End): November 30, 2016
Field of knowledge:Engineering - Sanitary Engineering - Water Supply and Wastewater Treatment
Principal researcher:Sergio Antonio Spinola Machado
Grantee:Fernando Henrique Cincotto
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated scholarship(s):14/02457-0 - Preparation of advanced hybrid nanomaterials based on functionalized polypyrrole/graphene/Sb nanoparticles for the laccase-mediated bioelectrochemical detection of endocrine disrupting compounds, BE.EP.DR


This project proposes to determine endocrine disruptors (testosterone and estradiol) in environmental samples and clinical. Will develop a methodology for the construction of electrochemical sensors coated glassy carbon nanocomposite-based graphene oxides (GO), gold nanoparticles (NpAu) and CdTe / CdS (quantum dots QDs). The electrode developed (GO / np-Au / QDs) is defined by measurements of atomic force microscopy (AFM), scanning electron microscopy (SEM), X-ray spectroscopy energy dispersive (EDX), and electrochemical techniques (cyclic voltammetry and electrochemical impedance spectroscopy - IEE). We will study the electrochemical behavior of endocrine disruptors in different supporting electrolytes and pH on the surface developed.The sensor developed and optimized allow for increased sensitivity and consequently the determination of endocrine disruptors testosterone and estradiol, with low detection limits. Therefore the sensor is applied to samples of river water and drinking water, industrial and domestic effluents, clinical analysis and sediment extracts. The detection of these interferences occur via oxidation / reduction of the direct electrochemical sensor surface, as much testosterone to estradiol, aiming to develop a system electrocatalytic, precise, sensitive, with potential for miniaturization and possibility of application "in situ" and real time.

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CANEVARI, T. C.; CINCOTTO, F. H.; NAKAMURA, M.; MACHADO, S. A. S.; TOMA, H. E.. Efficient electrochemical biosensors for ethynylestradiol based on the laccase enzyme supported on single walled carbon nanotubes decorated with nanocrystalline carbon quantum dots. ANALYTICAL METHODS, v. 8, n. 39, p. 7254-7259, . (12/18339-1, 13/24725-4)
CINCOTTO, FERNANDO HENRIQUE; MORAES, FERNANDO CRUZ; SPINOLA MACHADO, SERGIO ANTONIO. Graphene Nanosheets and Quantum Dots: A Smart Material for Electrochemical Applications. CHEMISTRY-A EUROPEAN JOURNAL, v. 20, n. 16, p. 4746-4753, . (12/18339-1)
CINCOTTO, FERNANDO H.; GOLINELLI, DIEGO L. C.; MACHADO, SERGIO A. S.; MORAES, FERNANDO C.. Electrochemical sensor based on reduced graphene oxide modified with palladium nanoparticles for determination of desipramine in urine samples. SENSORS AND ACTUATORS B-CHEMICAL, v. 239, p. 488-493, . (12/18339-1, 13/07296-2)
CANEVARI, THIAGO C.; PRADO, THIAGO M.; CINCOTTO, FERNANDO H.; MACHADO, SERGIO A. S.. Immobilization of ruthenium phthalocyanine on silica-coated multi-wall partially oriented carbon nanotubes: Electrochemical detection of fenitrothion pesticide. Materials Research Bulletin, v. 76, p. 41-47, . (12/18339-1, 11/23047-7)
CINCOTTO, FERNANDO H.; CANEVARI, THIAGO C.; CAMPOS, ANDERSON M.; LANDERS, RICHARD; MACHADO, SERGIO A. S.. Simultaneous determination of epinephrine and dopamine by electrochemical reduction on the hybrid material SiO2/graphene oxide decorated with Ag nanoparticles. ANALYST, v. 139, n. 18, p. 4634-4640, . (12/18339-1, 11/23047-7)
CINCOTTO, FERNANDO H.; CANEVARI, THIAGO C.; MACHADO, SERGIO A. S.. Highly Sensitive Electrochemical Sensor for Determination of Vitamin D in Mixtures of Water-Ethanol. Electroanalysis, v. 26, n. 12, p. 2783-2788, . (12/18339-1, 11/23047-7)
CANEVARI, THIAGO C.; CINCOTTO, FERNANDO H.; LANDERS, RICHARD; MACHADO, SERGIO A. S.. Synthesis and characterization of alpha-nickel (II) hydroxide particles on organic-inorganic matrix and its application in a sensitive electrochemical sensor for vitamin D determination. Electrochimica Acta, v. 147, p. 688-695, . (12/18339-1, 11/23047-7)
CESARINO, IVANA; CINCOTTO, FERNANDO H.; MACHADO, SERGIO A. S.. A synergistic combination of reduced graphene oxide and antimony nanoparticles for estriol hormone detection. SENSORS AND ACTUATORS B-CHEMICAL, v. 210, p. 453-459, . (12/18339-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CINCOTTO, Fernando Henrique. Detection of endocrine disruptors stradiol and estriol in environmental and clinical samples using modified electrodes with graphene, metal nanoparticles and quantum dots. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC/BT) São Carlos.

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