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Effect of Natural Killer cells on the in vitro differentiation of monocytes into dendritic cells in cancer patients: study of the mechanisms involved

Grant number: 12/23478-0
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): January 01, 2013
Effective date (End): June 30, 2016
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal Investigator:Jose Alexandre Marzagão Barbuto
Grantee:Maria Alejandra Clavijo Salomón
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):14/10290-9 - Modulation of natural killer cells on the differentiation and function of dendritic cells: study of the mechanisms involved and implications in cancer, BE.EP.DD


Natural Killer cells (NK) although known for their cytotoxic capacity, have been studied in recent years recognizing their role as modulators of other immune cells. Dendritic cells (DCs) in turn, sentinels of the immune system and link between innate and adaptive immunity, are cells widely studied in our laboratory and used as therapeutic strategy in cancer patients. DCs differentiated from monocytes (Mo) derived from healthy individuals in the presence of NK cells exhibit phenotypic and functional improvements while Mo-DCs differentiated in the presence of soluble factors secreted by NK cells present detrimental of phenotype and function, suggesting that cells NK modulate the differentiation and function of Mo-DCs by mechanisms that are still unexplored. It was seen that Mo-DCs derived from patients with neoplasms exhibit functional deficiencies. After vaccination with the strategy implemented in our laboratory, monocytes recover their ability to differentiate into dendritic cells, but the mechanism by which this improvement occurs is still unknown. Therefore, the aim of this project is to investigate the mechanisms involved in the modulation by NK cells and their subpopulations, of the monocyte differentiation into DCs and study the phenomenon in the context of cancer: before and after therapeutic vaccination. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CLAVIJO-SALOMON, MARIA A.; SALCEDO, ROSALBA; ROY, SOUMEN; DAS NEVES, RODRIGO X.; DZUTSEV, AMIRAN; SALES-CAMPOS, HELIOSWILTON; BORBELY, KAREN STEPONAVICIUS-CRUZ; SILLA, LUCIA; ORANGE, JORDAN S.; MACE, EMILY M.; et al. Human NK cells prime inflammatory DC precursors to induce Tc17 differentiation. BLOOD ADVANCES, v. 4, n. 16, p. 3990-4006, . (17/13686-9, 14/10290-9, 09/54599-5, 11/05331-0, 12/23478-0)
CLAVIJO-SALOMON, MARIA A.; BERGAMI-SANTOS, PATRICIA C.; BARBUTO, JOSE ALEXANDRE M.. Immunomonitoring reveals interruption of anergy after vaccination in a case of type-2-papillary renal cell carcinoma. Immunotherapy, v. 9, n. 4, p. 319-329, . (11/05331-0, 09/54599-5, 12/23478-0)
CLAVIJO-SALOMON, MARIA A.; RAMOS, RODRIGO N.; CRIPPA, ALEXANDRE; PIZZO, CELIA R.; BERGAMI-SANTOS, PATRICIA C.; BARBUTO, JOSE ALEXANDRE M.. Monocyte-derived dendritic cells reflect the immune functional status of a chromophobe renal cell carcinoma patient: Could it be a general phenomenon?. CANCER IMMUNOLOGY IMMUNOTHERAPY, v. 64, n. 2, p. 161-171, . (11/05331-0, 09/54599-5, 12/23478-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SALOMÓN, Maria Alejandra Clavijo. Natural Killer cells in the modulation of cell-mediated immunity in humans.. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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