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Effect of a resin infiltrant on white spot lesions treatment: in vitro, in situ and in vivo analyses

Grant number: 12/18579-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): February 01, 2013
Effective date (End): April 30, 2015
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Linda Wang
Grantee:Maria Cristina Carvalho de Almendra Freitas
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
Associated scholarship(s):13/23310-5 - Evaluation of the permeability of experimental resin infiltrants on the treatment of artificial white spot lesions, BE.EP.DR


Caries is a multifactorial disease that causes lesions on dental hard tissues ranging from incipient ultrastructural compromising level, up to total destruction of mineralized tissues. Currently, regarding the minimally invasive dentistry, it is of concern to treat and paralyze these early lesions interrupting its advance and avoiding more invasive treatment. There are several approaches to the treatment of these lesions and, more recently a resin agent was introduced with potential to infiltrate into the pores of caries-affected enamel, to stop and preventing its progression. This caries infiltrant is known by the trade name of Icon®. This project aims to evaluate the effect of Icon ® on artificial caries lesions produced by different protocols, and efficiency of this treatment after new acid challenge under in vitro and in situ experimental models, by means of superficial and longitudinal microhardness. The clinical effectiveness will be evaluated by a randomized controlled clinical trial comparing the use of infiltrant with fluoride varnish in white spot lesions. For the in vitro step, artificial caries lesions will be produced in 90 bovine enamel specimens through three different protocols (MC gel, MHDP solution and pH cycling). The specimens will be treated with infiltrant and subjected to acid challenge by new pH cycling. Superficial and longitudinal microhardness of specimens will be evaluated at three times: after demineralization by different protocols, after treatment with the infiltrant and after the new acid challenge. For the in situ step, 12 volunteers will participate, which will use palatal appliances containing four bovine enamel specimens for 14 days. During this period, volunteers will drop sucrose solution 8 times/day on specimens. Superficial and longitudinal microhardness of the specimens will be evaluated at three times: after demineralization, after treatment with the infiltrant and after the new acid challenge in situ. For clinical evaluation, assessments will be conducted directly and through photography, both following the modified criteria of Gorelick, Geiger and Gwinnett (1982) and ICDAS-II index. The use of QLF, as complement response, also will be used in the evaluations at the following times: immediately, 1 week, 4 and 8 weeks after the treatment. Data will be collected and statistically analyzed according to the distribution that will be checked. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
WANG, LINDA; CARVALHO DE ALMENDRA FREITAS, MARIA CRISTINA; PRAKKI, ANURADHA; MOSQUIM, VICTOR; MIRANDA GONZALEZ, ALEJANDRA HORTENCIA; RIOS, DANIELA; HONORIO, HEITOR MARQUES. Experimental self-etching resin infiltrants on the treatment of simulated carious white spot lesions. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 113, . (12/18579-2, 12/13160-3, 13/23310-5)
CARVALHO DE ALMENDRA FREITAS, MARIA CRISTINA; NUNES, LARISSA VASCONCELLOS; COMAR, LIVIA PICCHI; RIOS, DANIELA; MAGALHAES, ANA CAROLINA; HONORIO, HEITOR MARQUES; WANG, LINDA. In vitro effect of a resin infiltrant on different artificial caries-like enamel lesions. ARCHIVES OF ORAL BIOLOGY, v. 95, p. 118-124, . (12/18579-2, 12/13157-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FREITAS, Maria Cristina Carvalho de Almendra. Efffect of a resinous infiltrant on the tratment of white spot lesions: in vitro and in situ analysis. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Odontologia de Bauru (FOB/SDB) Bauru.

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