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Effectiveness of sucrose for pain relief during the vaccination of infants born preterm and exposed to this solution doused repeatedly during hospitalization in neonatal unit

Grant number: 12/03170-1
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): January 01, 2013
Effective date (End): June 30, 2017
Field of knowledge:Health Sciences - Nursing - Pediatric Nursing
Principal Investigator:Carmen Gracinda Silvan Scochi
Grantee:Mariana Firmino Daré
Host Institution: Escola de Enfermagem de Ribeirão Preto (EERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The newborn preterm are exposed to repeated painful procedures during hospitalization, even if adding exposure to acute pain in the vaccination. For the relief of pain in this population, several measures have been determined, including sucrose. However, it is clear that preterm infants have exposure and reactivity to different pain of newborns at term, without the use of interventions to their relief, and there is gap in the use of sucrose in the vaccination of PN and possible use effects at doses repeated over a prolonged period. Thus, we question whether the biobehavioral reactivity of preterm infants is equal to those born at term is subject to the use of sucrose 25% to relieve pain resulting from repeated vaccination until the sixth month of life. We hypothesized that the reactivity to pain in the vaccination of preterm infants is different from those born at term, even when subjected to sucrose for pain relief resulting from repeated vaccination until the sixth month of life. One has the general objective of examining the biobehavioral reactivity to pain resulting from repeated vaccination with the use of sucrose 25% in infants up to six months of life, comparing the preterm with those born at term. Method: This is a cohort study in which infants will be monitored in the vaccination until six months of life incomplete. The vaccination will be administered 2 ml of 25% sucrose orally in a single dose to the baby, two minutes before the procedure. It is estimated that in six months of data collection will be included 400 infants. Prematurity is considered a risk factor for reactivity to pain and maturity will be assessed from the gestational age recorded in the birth certificate. Will be measured as follows pain and stress indicators facial expressions, crying and heart rate, as well as contextual factors related to reactivity to pain (gender, current weight, birth weight, postnatal age, corrected gestational age, Apgar at the first and fifth minute and state of sleep and wakefulness before the procedure). It will be used bivariate analysis to compare the contextual variables. The statistical model will be considered covariates those contextual variables with statistically significant results (p <0.05) in bivariate tests. For variables related to pain manifestation (biobehavioral) in the case of parametric analysis, the statistical analysis within and between groups will be through the one-way ANOVA with repeated measures. The project was approved by the Research Ethics Committee. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
DARÉ, Mariana Firmino. Pain reativity in the vaccination of infants between two and five months of age, who received sucrose. 2017. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Enfermagem de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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