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Metabolomic analysis of associated endophytic fungi from Senna spectabilis using NMR and computational dereplication models

Grant number: 12/22206-7
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 01, 2013
Effective date (End): February 28, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Ian Castro-Gamboa
Grantee:Rafael Teixeira Freire
Supervisor: Arthur S. Edison
Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: University of Florida, Gainesville (UF), United States  
Associated to the scholarship:11/21623-0 - Development of a Pattern Recognition and Dereplication Software applied to Nuclear Magnetic Resonance Spectroscopy., BP.DR


The search for bioactive substances in natural products has stimulated integrated approaches in order to provide chemical information about the processes and interactions involved in the pharmacological responses from bioactive matrixes. Among these, metabolomics allows the qualitative and quantitative analysis of the molecular composition of an organism aiming the explanation of biological processes through the evaluation of metabolic responses. Our project aims to develop NMR analytical methods associated to dereplication computational models, in order to evaluate the metabolic profile produced by endophytic fungi associated with Senna spectabilis, a plant known to produce chemotypes with acetylcholinesterase inhibitory properties. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DENISE M. SELEGATO; RAFAEL T. FREIRE; ALBERTO TANNÚS; IAN CASTRO-GAMBOA. New Dereplication Method Applied to NMR-Based Metabolomics on Different Fusarium Species Isolated from Rhizosphere of Senna spectabilis. Journal of the Brazilian Chemical Society, v. 27, n. 8, p. 1421-1431, . (12/22206-7, 11/21623-0, 13/07600-3, 14/05935-0)

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