Production of nanobiomaterials based on nanohydroxyapatite/carbon nanotubes and polycaproloactone

Abstract

This project presents a new methodology for polymer scaffold fabrication with the incorporation of nanoparticles by electrospinning technique for bone tissue regeneration. Superhydrophilic vertical aligned carbon nanotube (VACNT) matrix will be used with nanohydroxiapatite (nHA) crystals obtained by electrodeposition method. The fabrication of tridimensional polymeric nanofibrous scaffolds is proposed with the homogeneous exposure of nHA crystals for bone growth. VACNTs will be produced using chemical vapor deposition assisted by microwave plasma and functionalizated by oxygen plasma in order to obtain their superhydrophilicity. Electrodeposition technique will be used to obtain homogeneous nHA crystals over superhydrofilic VACNTs. Polymeric nanofibrous scaffolds will be fabricated using eletrospinning technique. Polycaprolactone bioresorbable polymer is used as matrices. Will be evaluates several parameters to production of nanofibers, such as: applied tension, collector distance and superficial tension of polymeric solution. For the morphological and structural characterization will be used: Scanning electron microscopy, energy dispersive X-ray spectroscopy (EDS), fourier transform infrared and thermal analyses.We will be expecting that this new nanobiomaterial accelerate the osteointegration in vivo process. (AU)