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Role of hydrogen sulfide in orofacial nociception in rats

Grant number: 12/13888-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2012
Effective date (End): October 31, 2013
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Alberto Ferreira Donatti
Grantee:Rebeca Miranda de Araújo
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The hydrogen sulfide (H2S) gas is a substance formed from endogenous metabolism of L-cysteine by the action of cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and the 3-sulfur mercaptopiruvato transferase (3MST) (Szabo, 2007). Since the discovery of the endogenous pathway of cysteine - H2S, many efforts have been made to understand the physiological and pathological relations of this gas (Li et al., 2005; Szabo, 2007). Among the known functions of H2S in the body are to participate in the modulation of body temperature (Kwiatkoski et al., 2012), respiration (Hu et al., 2008), and nociception (Cunha et al., 2008). However, the action of H2S in orofacial nociception is not known. By this, the aim of this project is to study the role of H2S in orofacial nociception via the orofacial formalin test in rats. For this purpose, the rats receive subcutaneous injections of drugs that modulate positively or negatively towards nociception. These drugs are injected prior to the orofacial formalin test.(AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DONATTI, ALBERTO F.; ARAUJO, REBECA M.; SORIANO, RENATO N.; AZEVEDO, LEOPOLDO U.; LEITE-PANISSI, CHRISTIE A.; BRANCO, LUIZ G. S.. Role of hydrogen sulfide in the formalin-induced orofacial pain in rats. European Journal of Pharmacology, v. 738, p. 49-56, . (12/13888-7, 12/01417-0, 13/12850-9)

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