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Cytokine gene expression from cocultures of lymphocytes and dendritic cells derived from monocytes of HIV-infected children and adolescents

Grant number: 12/06525-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): November 01, 2012
Effective date (End): August 31, 2014
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Maria Marluce dos Santos Vilela
Grantee:Jéssica Santana Bernachi
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The aim of this study is to characterize in HIV-infected children and adolescents the response in cocultures of monocyte derived dendritic cells (MDDC) and lymphocytes to inactivated HIV particles. The dendritic cells will be evaluated by flow cytometry for expression of CD80, CD83, CD86, CD40 and HLA-DR and by PCR-array followed by Real Time PCR for cytokines mRNA expression of IFN-gama, IFN-alfa, TNF-alfa, TGF-beta 1, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 e IL-15. The results from patients with viral load> 1000 copies/mL and with undetectable viral load will be compared using statistical tests appropriate to the distribution of data (significance level, p <0.05). (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BERNACHI, Jéssica Santana. Monocyte-derived dendritic cell maturation and function from HIV-infected children and adolescents. 2014. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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