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Influence of tomato and lycopene supplementation on the cardiac remodeling after acute myocardial infarction

Grant number: 12/16471-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2013
Effective date (End): February 28, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Marcos Ferreira Minicucci
Grantee:Bruna Letícia Buzati Pereira
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Cardiovascular diseases are the major cause of death in the world and it is estimated that, in 2030, they will be responsible for approximately 23.6 million deaths. Among cardiovascular diseases, we can highlight acute coronary syndromes, especially acute myocardial infarction (AMI). Heart failure is a frequent complication after the AMI and several factors influence its development, one of these factors is cardiac remodeling. The increase oxidative stress and inflammation process are associated with cardiac remodeling after the AMI. Due to the great economic and social impact and the high mortality rates, it is important to identify other factors that attenuate cardiac remodeling process. Among these factors are the food supplementation with antioxidant properties, such as tomato (Lycopersicon esculentum), and one of its primary constituents, lycopene. However, the tomato and lycopene influence on cardiac remodeling after the AMI has not been studied yet.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PEREIRA, BRUNA L. B.; ARRUDA, FERNANDA C. O.; REIS, PATRICIA P.; FELIX, TAINARA F.; SANTOS, PRISCILA P.; RAFACHO, BRUNA P.; GONCALVES, ANDREA F.; CLARO, RENAN T.; AZEVEDO, PAULA S.; POLEGATO, BERTHA F.; et al. Tomato (Lycopersicon esculentum) Supplementation Induces Changes in Cardiac miRNA Expression, Reduces Oxidative Stress and Left Ventricular Mass, and Improves Diastolic Function. NUTRIENTS, v. 7, n. 11, p. 9640-9649, . (12/16471-0, 12/17414-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PEREIRA, Bruna Letícia Buzati. Influência da suplementação de tomate e licopeno na remodelação cardíaca após infarto agudo do miocárdio. 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.

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