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Genital system development and reproductive function of female offspring of rats exposed to cisplatin during peri-puberty.

Grant number: 12/12970-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): November 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Biological Sciences - Morphology - Embryology
Principal Investigator:Wilma de Grava Kempinas
Grantee:Patrícia Villela e Silva
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Cisplatin is a drug widely used in chemotherapy against several types of human malignant tumors such as ovarian cancer, head and neck, bladder, lung, and particularly, testicular cancer, one of the tumor that most affect men in reproductive age. Its mechanism of action include induction of cell apoptosis, however, can also cause some adverse effects on reproduction, for example, DNA damage in germ cells, resulting in impaired spermatogenesis. There are several studies that describe the adverse effects of cisplatin on the male reproductive system, but there are few that report the association between cisplatin and the development of female reproductive system of the offspring of rats exposed to the drug. Thus, this study aims to investigate the possible adverse effects on reproductive parameters of female offspring of rats exposed to 1 mg / kg / day cisplatin for 3 weeks, during peri-puberty. For this, the following parameters will be evaluated: fetal ovarian histology, measurement of anogenital distance, number of areolas / nipples, age of vaginal opening and first estrus (indicative of puberty installation), weight and histological evaluation of the reproductive organs (uterus and ovaries), regularity of the estrous cycle,sexual behavior, fertility, hormonal levels and immunohistochemical analysis of androgen and estrogen receptors in uterine tissue. The goal of this proposal is to contribute to the updating of scientific knowledge about the possible adverse effects of the drug on the development and female reproductive function, through the dissemination of results through publications in international and indexed impact journals, as well as communications at scientific meetings in the area, besides the preparation of qualified human resources in Biology and Toxicology of Reproduction.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VILLELA E SILVA, PATRICIA; DA SILVA, RAQUEL FRENEDOSO; BORGES, CIBELE DOS SANTOS; CAVARIANI, MARILIA MARTINS; DINIZ DE ALMEIDA FRANCIA, CAMILA CONTIN; BARBOSA JUNIOR, FERNANDO; KEMPINAS, WILMA DE GRAVA. Sexual differentiation and reproductive development of female rat offspring after paternal exposure to the anti-tumor pharmaceutical cisplatin. REPRODUCTIVE TOXICOLOGY, v. 60, p. 112-122, . (12/12970-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Patrícia Villela e. Avaliação do desenvolvimento do sistema genital e da funçao reprodutiva da prole feminina de ratos Wistar expostos à cisplatina durante a peri-puberdade. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.

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