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Evaluation of ins and expiratory muscles in respiratory diseases

Grant number: 12/18404-8
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): October 01, 2012
Effective date (End): September 30, 2016
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Pedro Caruso
Grantee:Pauliane Vieira Santana
Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:10/08947-9 - Evaluation of INS and expiratory muscles in respiratory diseases, AP.TEM

Abstract

The evaluation of the kinematic of the respiratory muscles (ins and expiratory) and their functional and clinical contributions to respiratory diseases are outstanding in the scientific context. Previous studies have confirmed that chronic obstructive pulmonary disease (COPD) and lung fibrosis may lead to disadvantageous conformation for some respiratory muscles even at rest. While the diaphragm can be flattened in COPD patients, in the other hand it can be extremely shortened in lung fibrosis. As a consequence, its ability to generate strength in these two extreme situations based on force-length graph (principle of Frank-Starling) is severely impaired. This disadvantage of the diaphragm in association with a greater recruitment of inspiratory-accessory muscles are believed to contribute substantially for a higher breathlessness. Regarding the respiratory mechanics yet, the ventilatory muscles will have important influence on other diseases too. A typical situation is the failure of weaning from the mechanical ventilator because of weakness or fatigue from the diaphragm. Other illustrative condition represents the intense breathlessness referred by the individuals with diaphragm paralysis, where this symptom can reflect exactly the inability of the diaphragm to generate strength sufficiently for the inspiration. This dysfunction of the diaphragm, however, is likely not the only mechanism of the dyspnea in this disease, since some patients maintain the symptom after surgical correction of the diaphragmatic insertion. Therefore, it's clear the importance of future studies about the respiratory mechanics, specifically focused on ventilatory muscles, in diverse respiratory diseases. Taking also account the importance of having centers of reference linking to this field in our country, we proposed the current study comprised of four investigations: (1) with COPD, (2) lung fibrosis, (3) weaning of mechanical ventilation, (4) and paralysis of diaphragm. Novel and recognizable diagnostic techniques will be applied, as maximal magnetic stimulation of phrenic nerve, transdiaphragmatic pressure measurement, electromyogram of accessory muscles for ventilation, and synchrony of thoracic subcompartments during respirations, with all measurements being done at rest and during cardiopulmonary exercise as well. Our objective is the human and diagnostic development about the knowledge of dysfunctions of the ventilatory muscles and its repercussions, making possible a comprehensive understanding of the pathophysiology and, in this way, new design of future interventions for these respiratory diseases. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTANA, PAULIANE VIEIRA; CARDENAS, LETICIA ZUMPANO; FERREIRA, JEFERSON GEORGE; DE CARVALHO, CARLOS ROBERTO RIBEIRO; DE ALBUQUERQUE, ANDRE LUIS PEREIRA; CARUSO, PEDRO. Thoracoabdominal asynchrony associates with exercise intolerance in fibrotic interstitial lung diseases. Respirology, v. 26, n. 7, . (12/18404-8)
SANTANA, PAULIANE VIEIRA; CARDENAS, LETICIA ZUMPANO; PEREIRA DE ALBUQUERQUE, ANDRE LUIS; RIBEIRO DE CARVALHO, CARLOS ROBERTO; CARUSO, PEDRO. Diaphragmatic ultrasound findings correlate with dyspnea, exercise tolerance, health-related quality of life and lung function in patients with fibrotic interstitial lung disease. BMC PULMONARY MEDICINE, v. 19, n. 1, . (12/18404-8)
PAULIANE VIEIRA SANTANA; LETICIA ZUMPANO CARDENAS; ANDRÉ LUIS PEREIRA DE ALBUQUERQUE; CARLOS ROBERTO RIBEIRO DE CARVALHO; PEDRO CARUSO. Ultrassonografia diafragmática: uma revisão de seus aspectos metodológicos e usos clínicos. Jornal Brasileiro de Pneumologia, v. 46, n. 6, . (12/18404-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTANA, Pauliane Vieira. Evaluation of inspiratory and expiratory musculature in interstitial fibrosing lung disease compared to healthy individuals. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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