Scholarship 12/16288-0 - Genômica funcional, Transcriptoma - BV FAPESP
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FUNCTIONAL ANALYSIS OF THE PRESENCE OF B CHROMOSOME USING Astatotilapia latifasciata (CICHLID FISH) AS A MODEL

Grant number: 12/16288-0
Support Opportunities:Scholarships in Brazil - Doctorate
Start date until: November 01, 2012
End date until: July 31, 2015
Field of knowledge:Biological Sciences - Genetics - Animal Genetics
Principal Investigator:César Martins
Grantee:Diego Ferreira Marques
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Supernumerary chromosomes (B chromosomes) are extra elements not homologous to the A complement and are present in approximately 15% of eukaryotes species. Recent studies with these elements has been more focused investigations on cytogenetic level and functional aspects have been little explored. Among the fish species the cichlids have received great scientific interest since some groups have suffered rapid and extensive process of adaptive radiation. To date B chromosomes have been described for approximately 20 cichlid species ranging in number from one to three. As for genomic data, some species of the group as Oreochromis niloticus and Metriaclima lombardoi for example have already sequenced genomes and others are in the process of sequencing. Considering the aspects mentioned, linked to the possibility of using tools that integrate genomic and cytogenetic data this project aims to identify functional genes present on chromosome B and their possible roles in the biology of the species Astatotilapia latifasciata by transcriptome analysis of target tissues that suffer action of these genes. These analyzes are promising for elucidating several questions that guide the biology of B chromosomes opening prospects for clarifying the origin, maintenance and evolution of these genomic elements in eukaryotes.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MARQUES, Diego Ferreira. Functional analysis of B chromosome presence using cichlid Astatotilapia latifasciata as model. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.

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