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Characterization of global gene expression associated with feed efficiency in Nelore cattle

Grant number: 12/14792-3
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2012
Effective date (End): February 28, 2015
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal researcher:Joanir Pereira Eler
Grantee:Pâmela Almeida Alexandre
Home Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
Associated scholarship(s):14/00307-1 - A systems genetics approach for improving feed efficiency in Nellore cattle, BE.EP.MS


The world population growth estimated for the coming decades and the consequent need to produce more food brings to the Brazilian beef industry, considering its importance in global market, the challenge of increase production while reducing the environmental impact of meat chain. One way is by selecting animals with high feed efficiency, which not only produce more meat per kilogram of food consumed, but also emit less methane and produce less manure per kilogram of meat produced. In this project, it is proposed to characterize the phenotype of high feed efficiency in terms of global gene expression profile (RNA-seq) in liver samples from Nellore bulls challenged in feedlot for 70 days and selected into two groups (high and low feed efficiency) according to the measure of residual intake and body weight gain (RIG). Finally, potential feed efficiency associated pathways will be identified using the results of gene expression, and thus the mechanisms that cause individuals to differ in their response to diet will be clarified. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALEXANDRE, PAMELA A.; KOGELMAN, LISETTE J. A.; SANTANA, MIGUEL H. A.; PASSARELLI, DANIELLE; PULZ, LIDIA H.; FANTINATO-NETO, PAULO; SILVA, PAULO L.; LEME, PAULO R.; STREFEZZI, RICARDO F.; COUTINHO, LUIZ L.; et al. Liver transcriptomic networks reveal main biological processes associated with feed efficiency in beef cattle. BMC Genomics, v. 16, . (12/14792-3, 14/00307-1, 14/07566-2, 14/02493-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ALEXANDRE, Pâmela Almeida. Characterization of global hepatic gene expression profile associated with feed efficiency in Nelore cattle. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Zootecnica e Engenharia de Alimentos (FZE/BT) Pirassununga.

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