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Search for a Molecular Signature of Receptivity in Cattle by Mass Spectrometry

Grant number: 12/07206-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): October 01, 2012
Effective date (End): September 30, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Marcos Nogueira Eberlin
Grantee:Katia Roberta Anacleto Belaz
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:10/51677-2 - Development of new mass spectrometry techniques and their general applications in science: chemistry, biochemistry, material sciences, forensics, medicine, food science, pharmaceutical and veterinary medicine, AP.TEM

Abstract

Required increases in reproductive efficiency in cattle depends on the understanding of the endocrine, cellular and molecular results in higher conception rates in cows. The project's central thesis is that there is a "molecular signature" associated with the optimal conditions of maternal responsiveness to the embryo. This signature constitutes a characteristic pattern of abundance of biochemical molecules of various natures. The overall objective is to characterize and quantify the number of molecules existing in the uterus and / or oviducts associated with maternal responsiveness to both, if use of the proteome study of reproductive and maternal lipidoma by MALDI-MS

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Scientific publications (12)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LANZARINI, FRANCIELE; PEREIRA, FERNANDA ALVES; CAMARGO, JANINE DE; OLIVEIRA, ANDRESSA MINOZZO; BELAZ, KATIA ROBERTA ANACLETO; MELENDEZ-PEREZ, JOSE JAVIER; EBERLIN, MARCOS NOGUEIRA; BRUM, MARIO CELSO SPEROTTO; MESQUITA, FERNANDO SILVEIRA; SUDANO, MATEUS JOSE. ELOVL5 Participates in Embryonic Lipid Determination of Cellular Membranes and Cytoplasmic Droplets. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 3, . (12/07206-0)
NEGRAO, FERNANDA; ABANADES, DANIEL R.; JAEEGER, CAROLINE F.; ROCHA, DANIELE F. O.; BELAZ, KATIA R. A.; GIORGIO, SELMA; EBERLIN, MARCOS N.; ANGOLINI, CELIO F. F.. Lipidomic alterations of in vitro macrophage infection by L-infantum and L-amazonensis. MOLECULAR BIOSYSTEMS, v. 13, n. 11, p. 2401-2406, . (16/11517-2, 15/23767-0, 12/07206-0, 13/11100-6, 10/51677-2)
PORCARI, ANDREIA M.; FERNANDES, GABRIEL D.; BELAZ, KATIA ROBERTA A.; SCHWAB, NICOLAS V.; SANTOS, VANESSA G.; ALBERICI, ROSANA M.; GROMOVA, VARVARA A.; EBERLIN, MARCOS N.; LEBEDEV, ALBERT T.; TATA, ALESSANDRA. High throughput MS techniques for caviar lipidomics. ANALYTICAL METHODS, v. 6, n. 8, p. 2436-2443, . (11/06191-7, 12/07206-0)
PITANGUI-MOLINA, CAROLINE P.; VIREQUEA, ALESSANDRA A.; TATA, ALESSANDRA; BELAZ, KATIA ROBERTA A.; SANTOS, VANESSA G.; FERREIRA, CHRISTINA R.; EBERLIN, MARCOS N.; SILVA-DE-SA, MARCOS FELIPE; FERRIANIA, RUI A.; ROSA-E-SILVA, ANA CAROLINA J. S.. Effect of soybean phosphatidylcholine on lipid profile of bovine oocytes matured in vitro. Chemistry and Physics of Lipids, v. 204, p. 76-84, . (11/06191-7, 12/07206-0)
JAEGGER, C. F.; NEGRAO, F.; ASSIS, D. M.; BELAZ, K. R. A.; ANGOLINI, C. F. F.; FERNANDES, A. M. A. P.; SANTOS, V. G.; PIMENTEL, A.; ABANADES, D. R.; GIORGIO, S.; et al. MALDI MS imaging investigation of the host response to visceral leishmaniasis. MOLECULAR BIOSYSTEMS, v. 13, n. 10, p. 1946-1953, . (16/11517-2, 15/23767-0, 13/11100-6, 12/07206-0)
ROCHA, DANIELE F. O.; CUNHA, CRISTIANE M. S.; BELAZ, KATIA ROBERTA A.; DOS SANTOS, FABIO N.; HINZ, ROBERT H.; PEREIRA, ADRIANA; WICKET, ESTER; ANDRADE, LIDIANE M.; NASCIMENTO, CLAUDIO A. O.; VISCONTI, ALEXANDRE; et al. Lipid and protein fingerprinting for Fusarium oxysporum f. sp cubense strain-level classification. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 409, n. 29, p. 6803-6812, . (13/11100-6, 12/07206-0)
GARCIA, N. L.; RODRIGUES-MOTTA, M.; BELAZ, K. R. A.; TATA, A.; FRANCA, M. R.; BINELLI, M.; EBERLIN, M. N.. An EM-type approach for classification of bivariate MALDI-MS data and identification of high fertility markers. ENVIRONMETRICS, v. 30, n. 3, . (11/06191-7, 12/07206-0)
SANTOS, P. H.; FONTES, P. K.; FRANCHI, F. F.; NOGUEIRA, M. F. G.; BELAZ, K. R. A.; TATA, A.; EBERLIN, M. N.; SUDANO, M. J.; BARROS, C. M.; CASTILHO, A. C. S.. Lipid profiles of follicular fluid from cows submitted to ovarian superstimulation. Theriogenology, v. 94, p. 64-70, . (13/11480-3, 12/07206-0)
DOS SANTOS, FABIO NEVES; TATA, ALESSANDRA; ANACLETO BELAZ, KATIA ROBERTA; ARGOLO MAGALHAES, DILZE MARIA; MARTINS NEWMAN LUZ, EDNA DORA; EBERLIN, MARCOS NOGUEIRA. Major phytopathogens and strains from cocoa (Theobroma cacao L.) are differentiated by MALDI-MS lipid and/or peptide/protein profiles. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 409, n. 7, p. 1765-1777, . (11/06191-7, 12/07206-0)
ANNES, KELLY; SUDANO, MATEUS JOSE; BELAZ, KATIA ROBERTA A.; TATA, ALESSANDRA; SANTOS, VANESSA GONCALVES; DA FONSECA JUNIOR, ALDCEJAM MARTINS; DOS SANTOS, ERIKA CRISTINA; EBERLIN, MARCOS NOGUEIRA; MILAZZOTTO, MARCELLA PECORA. Lipid characterization of in vitro-produced bovine embryos with distinct kinetics of development. ZYGOTE, v. 27, n. 6, p. 413-422, . (11/06191-7, 12/10351-2, 12/07206-0, 13/13199-0)
BELAZ, KATIA ROBERTA A.; TATA, ALESSANDRA; FRANCA, MOANA R.; SANTOS DA SILVA, MARESSA I.; VENDRAMINI, PEDRO HENRIQUE; FERNANDES, ANNA MARIA A. P.; D'ALEXANDRI, FABIO L.; EBERLIN, MARCOS N.; BINELLI, MARIO. Phospholipid Profile and Distribution in the Receptive Oviduct and Uterus During Early Diestrus in Cattle. BIOLOGY OF REPRODUCTION, v. 95, n. 6, . (11/03226-4, 11/06191-7, 12/07206-0)
SUDANO, MATEUS J.; RASCADO, TATIANA D. S.; TATA, ALESSANDRA; BELAZ, KATIA R. A.; SANTOS, VANESSA G.; VALENTE, RONIELE S.; MESQUITA, FERNANDO S.; FERREIRA, CHRISTINA R.; ARAUJO, JOAO P.; EBERLIN, MARCOS N.; et al. Lipidome signatures in early bovine embryo development. Theriogenology, v. 86, n. 2, p. 472-484, . (11/06191-7, 12/07206-0)

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