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Does the "mediterranization" of a Brazilian meal induce cardiometabolic benefits?

Grant number: 12/05503-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2012
Effective date (End): December 31, 2015
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Sandra Roberta Gouvea Ferreira Vivolo
Grantee:Milena Monfort Pires
Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):14/08470-9 - Critical thinking on Mediterranean diet with emphasis on olive oil: comparisons between in loco interventions and developed in Brazil, BE.EP.DR


Changes in dietary patterns and physical activity of populations have contributed to elevate the incidence of non-communicable chronic diseases, mainly those associated with increased adiposity. This picture tends to increase cardiovascular mortality motivating health experts to take preventive measures. Studies have showed that populations that consume the typical Mediterranean diet have lower cardiovascular disease mortality. The benefits of this high-fiber and high-unsaturated fat diet derived in part from the effects of these nutrients on the inflammatory status that precedes metabolic diseases and atherosclerosis. This study assess the effects of a single meal change of Brazilian menu in order to approximate to the precepts of the Mediterranean diet, on lipid and glucose metabolism, as well as on subclinical inflammation and expression of proinflammatory genes. This is cross-over open trial with a 10-week duration. Overweight adults without diabetes will be included. Participants will undergo two 4-week breakfast interventions in random order, with wash-out of two weeks between them. Isocaloric breakfasts (typically Brazilian and mediterranized) will differ according to fiber and fatty acids contents. Before and at the end of each intervention, they will be submitted to an acute test consisted of a breakfast with distinct fatty acids composition (rich in saturated or in unsaturated fat) depending on the intervention. Challenge tests include basal and blood sample collections from 0 to 240 minutes for plasma glucose, insulin, lipids and inflammatory markers determinations; areas under the curves will be calculated. Expression of certain pro-inflammatory genes in leukocytes before and after each intervention will be analyzed. Student t test or the corresponding non-parametric test will be employed and p <0.05 considered significant.

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONFORT-PIRES, MILENA; FERREIRA, SANDRA ROBERTA G.. Modification in a single meal is sufficient to provoke benefits in inflammatory responses of individuals at low-to-moderate cardiometabolic risk. Clinical Nutrition, v. 35, n. 6, p. 1242-1250, . (12/05503-8, 12/05487-2)
MONFORT-PIRES, MILENA; CRISMA, AMANDA RABELLO; BORDIN, SILVANA; FERREIRA, SANDRA ROBERTA G.. Greater expression of postprandial inflammatory genes in humans after intervention with saturated when compared to unsaturated fatty acids. EUROPEAN JOURNAL OF NUTRITION, v. 57, n. 8, p. 2887-2895, . (12/05503-8, 12/05487-2)
MONFORT-PIRES, MILENA; DELGADO-LISTA, JAVIER; GOMEZ-DELGADO, FRANCISCO; LOPEZ-MIRANDA, JOSE; PEREZ-MARTINEZ, PABLO; GOUVEA FERREIRA, SANDRA ROBERTA. Impact of the Content of Fatty Acids of Oral Fat Tolerance Tests on Postprandial Triglyceridemia: Systematic Review and Meta-Analysis. NUTRIENTS, v. 8, n. 9, . (12/05503-8, 12/05487-2)
MONFORT-PIRES, MILENA; FERREIRA, SANDRA ROBERTA G.. Inflammatory and metabolic responses to dietary intervention differ among individuals at distinct cardiometabolic risk levels. NUTRITION, v. 33, p. 331-337, . (12/05503-8, 12/05487-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PIRES, Milena Monfort. Modification of a Brazilian meal including Mediterranean components induces cardiometabolic benefits. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) São Paulo.

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