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Synthesis of anhydride fragment from tautomycetin

Grant number: 12/11220-9
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): September 01, 2012
Effective date (End): February 28, 2013
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Luiz Carlos Dias
Grantee:Danilo Pereira de Sant'Ana
Supervisor: Jean-Marc Campagne
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), France  
Associated to the scholarship:09/09176-9 - Total synthesis of the natural products dictiostatin, Tautomycetin and analogues, BP.DR


Tautomycetin (TTN) is natural polyketide isolated in 1989 from Streptomyces griseochromogenes. TTN is more seletive inhibitor of PP1 (serine/threonine phosphatase) known until now and it is a potent protein tyrosine phosphatase-2 (SHP2) inhibitor. The phosphatases protein have been investigated as a new strategy for cancer therapy. This project aim to develop a convergent synthetic route which we shall obtain significant amount of TTN in order to investigated its biologic activity, as well as, allow us to achieve simpler analogos planned in rational way. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SUPPO, JEAN-SIMON; DE SANT'ANA, DANILO PEREIRA; DIAS, LUIZ CARLOS; DE FIGUEIREDO, RENATA MARCIA; CAMPAGNE, JEAN-MARC. Efficient and Practical Procedure for the Esterification of the Free alpha-Carboxylic Acid of Amino Acid Residues with beta-(Trimethylsilyl)ethoxymethyl Chloride and Triisopropylsilyl Chloride. SYNTHESIS-STUTTGART, v. 46, n. 22, p. 3075-3084, . (12/11220-9)
DE SANT'ANA, DANILO PEREIRA; REZENDE JUNIOR, CELSO DE OLIVEIRA; CAMPAGNE, JEAN-MARC; DIAS, LUIZ CARLOS; DE FIGUEIREDO, RENATA MARCIA. Synthetic Studies toward the Total Synthesis of Tautomycetin. Journal of Organic Chemistry, v. 84, n. 19, p. 12344-12357, . (14/50249-8, 15/08541-6, 12/11220-9)

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