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Effects of low level laser therapy on modulation of the transcriptome, immunohistochemistry of muscle tissue and physical performance of young men undergoing physical strength training

Grant number: 12/05919-0
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): December 15, 2012
Effective date (End): July 14, 2013
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Nivaldo Antonio Parizotto
Grantee:Cleber Ferraresi
Supervisor: Michael R. Hamblin
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Research place: Harvard University, Boston, United States  
Associated to the scholarship:10/07194-7 - Use of low-level laser and light-emitting diode therapy to increase muscle performance: from in vitro and experimental studies to clinical applications, BP.DR


Recent studies have used the phototherapy by low-level laser therapy (LLLT) to improvement muscle performance in humans, decreasing fatigue and increasing muscle torque. Aligned to these effects, LLLT possibly promotes structural changes in muscle tissue such as transition between fiber types, increased vascularization, mitochondrial density and satellite cells, pointing as some of the possible mechanisms that explain the good results of this therapy. Thus we have the prospect of representing the effects of phototherapy by LLLT on human muscle performance in strength exercises, investigating mainly adaptations on indicators of muscle performance, immunohistochemical and genetic. To achieve these objectives, the randomized clinical trial (FAPESP 2010/07194-7 process) is being performed. This study involves 30 volunteers (young and healthy men) who underwent physical strength training in leg press associated with LLLT. In addition for signaling pathways of genes related to hypertrophy and atrophy, satellite cells and mitochondrial biogenesis, now we have new perspective to analyze the whole human transcriptome (microarray analysis) in association with possible structural changes of muscle fibers (immunohistochemical analysis). This cooperative study between the UFSCar and Harvard Medical School will allow the understanding of all adjustments described above, which are extremely important to elucidate some mechanisms of action of the LLLT on muscle performance as reported in previous studies. Also, this study represents a major advance in knowledge in biotechnology, physiotherapy and sports medicine. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERRARESI, CLEBER; BERTUCCI, DANILO; SCHIAVINATO, JOSIANE; REIFF, RODRIGO; ARAUJO, AMELIA; PANEPUCCI, RODRIGO; MATHEUCCI, JR., EUCLIDES; CUNHA, ANDERSON FERREIRA; ARAKELIAN, VIVIAN MARIA; HAMBLIN, MICHAEL R.; et al. Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed-Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION, v. 95, n. 10, p. 746-757, . (12/05919-0, 10/07194-7)
FERRARESI, CLEBER; PARIZOTTO, NIVALDO ANTONIO; PIRES DE SOUSA, MARCELO VICTOR; KAIPPERT, BEATRIZ; HUANG, YING-YING; KOISO, TOMOHARU; BAGNATO, VANDERLEI SALVADOR; HAMBLIN, MICHAEL R.. Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation. Journal of Biophotonics, v. 8, n. 9, p. 740-754, . (12/05919-0, 10/07194-7)
VATANSEVER, FATMA; DE MELO, WANESSA C. M. A.; AVCI, PINAR; VECCHIO, DANIELA; SADASIVAM, MAGESH; GUPTA, ASHEESH; CHANDRAN, RAKKIYAPPAN; KARIMI, MAHDI; PARIZOTTO, NIVALDO A.; YIN, RUI; et al. Antimicrobial strategies centered around reactive oxygen species - bactericidal antibiotics, photodynamic therapy, and beyond. FEMS MICROBIOLOGY REVIEWS, v. 37, n. 6, p. 955-989, . (11/06240-8, 12/05919-0, 10/07194-7)
FERRARESI, CLEBER; PIRES DE SOUSA, MARCELO VICTOR; HUANG, YING-YING; BAGNATO, VANDERLEI SALVADOR; PARIZOTTO, NIVALDO ANTONIO; HAMBLIN, MICHAEL R.. Time response of increases in ATP and muscle resistance to fatigue after low-level laser (light) therapy (LLLT) in mice. Lasers in Medical Science, v. 30, n. 4, p. 1259-1267, . (12/05919-0, 10/07194-7)
FERRARESI, CLEBER; DOS SANTOS, RICARDO VINICIUS; MARQUES, GUILHERME; ZANGRANDE, MARCELO; LEONALDO, ROBERLEY; HAMBLIN, MICHAEL R.; BAGNATO, VANDERLEI SALVADOR; PARIZOTTO, NIVALDO ANTONIO. Light-emitting diode therapy (LEDT) before matches prevents increase in creatine kinase with a light dose response in volleyball players. Lasers in Medical Science, v. 30, n. 4, p. 1281-1287, . (12/05919-0, 10/07194-7)
DE BRITO VIEIRA, WOUBER HERICKSON; BEZERRA, RAPHAEL MACHADO; SALDANHA QUEIROZ, RENATA ALENCAR; BRAGA MACIEL, NICIA FARIAS; PARIZOTTO, NIVALDO ANTONIO; FERRARESI, CLEBER. Use of Low-Level Laser Therapy (808 nm) to Muscle Fatigue Resistance: A Randomized Double-Blind Crossover Trial. Photomedicine and Laser Surgery, v. 32, n. 12, p. 678-685, . (12/05919-0, 10/07194-7)
FERRARESI, CLEBER; KAIPPERT, BEATRIZ; AVCI, PINAR; HUANG, YING-YING; DE SOUSA, MARCELO V. P.; BAGNATO, VANDERLEI S.; PARIZOTTO, NIVALDO A.; HAMBLIN, MICHAEL R.. Low-level Laser (Light) Therapy Increases Mitochondrial Membrane Potential and ATP Synthesis in C2C12 Myotubes with a Peak Response at 3-6 h. Photochemistry and Photobiology, v. 91, n. 2, p. 411-416, . (12/05919-0, 10/07194-7)

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