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Aggregatibacter actinomycetemcomitans: analysis of the virulence and the transcriptomes of strains of JP2-like and non-JP2 serotype b lineages in the induction of experimental peri-implantitis in animal

Grant number: 12/05911-9
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): September 02, 2012
Effective date (End): September 01, 2013
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Marcia Pinto Alves Mayer
Grantee:Maike Paulino da Silva
Supervisor: Casey Chen
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Southern California (USC), United States  
Associated to the scholarship:11/18683-1 - Aggregatibacter actinomycetemcomitans: gene transcription profile of clinical isolates and the role of immune response against omp29 in the induction of experimental periodontitis in animal., BP.DR


Certain clonal types as well as specific serotypes of Aggregatibacter actinomycetemcomitans seem to be related with aggressive periodontitis, indicating that the virulence potential should vary among strains. Thus, to contribute to the understanding of the role of variable virulence of A. actinomycetemcomitans, this study aims to evaluate the transcriptomes of A. actinomycetemcomitans JP2-like and non-JP2 serotype b lineages in vitro. In addition, the peri-implant response to implants inoculated with A. actinomycetemcomitans JP2-like and non-JP2 serotype b lineages will be evaluated in a in vivo experimental peri-implantitis model by analyzing characterization the Th subsets (Th17 and Treg) and their associated cytokines in peri-implant mucosal tissues in response to A. actinomycetemcomitans biofilm on titanium implants and the induction of bone resorption by micro-CT evaluation, with concomitant 3D reconstruction of peri-implant bone. Afterwards, the data of the in vivo experiments will be correlated with expression of virulence associated genes. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
REBEIS, ESTELA SANCHES; ALBUQUERQUE-SOUZA, EMMANUEL; DA SILVA, MAIKE PAULINO; GIUDICISSI, MARCELA; MAYER, MARCIA P. A.; SARAIVA, LUCIANA. Effect of periodontal treatment on Aggregatibacter actinomycetemcomitans colonization and serum IgG levels against A-actinomycetemcomitans serotypes and Omp29 of aggressive periodontitis patients. ORAL DISEASES, v. 25, n. 2, p. 569-579, . (13/26381-0, 12/05911-9, 10/16162-1)

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