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Bioaccessibility and bioavailability of nutrients and toxic elements in lettuce (Lactuca sativa)

Grant number: 12/15020-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2012
Effective date (End): August 31, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Solange Cadore
Grantee:Emanueli Do Nascimento da Silva
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated scholarship(s):14/15425-0 - Selenium biofortification of lettuce: study of selenium bioaccessibility and speciation in the edible portion of the plant, BE.EP.DR


In this study the total content and bioaccessible and bioavailable contents of Cd, Pb, Zn and Fe in lettuce will be evaluated. For studies of bioavailability and bioaccessibility the procedure employed will be the in vitro gastrointestinal digestion, followed by studies on absorption of minerals by the Caco-2 cells, which are a model of epithelial cell extracted from the human colon. The techniques used are optical emission spectrometry with inductively coupled plasma ICP OES and/or graphite furnace atomic absorption spectrometry GF AAS for the quantification of the total content of the elements. For the determination of the fractions bioaccessible and bioavailable, the choice of technique will be made by assessing the level of element concentration in the sample. Considering that the Brazilian population is not aware of the actual nutritional value of food, it is hoped this study make a contribution to the knowledge of the nutritional value and toxic effect in lettuce, in relation to the analytes studied. Furthermore, we will evaluate the effective absorption of these metals by the human body by means of bioavailability studies.

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, EMANUELI DO NASCIMENTO; CIDADE, MIRLA; HEERDT, GABRIEL; RIBESSI, RAFAEL L.; MORGON, NELSON H.; CADORE, SOLANGE. Effect of Selenite and Selenate Application on Mineral Composition of Lettuce Plants Cultivated Under Hydroponic Conditions: Nutritional Balance Overview Using a Multifaceted Study. Journal of the Brazilian Chemical Society, v. 29, n. 2, p. 371-379, . (12/15020-4, 14/15425-0, 08/57808-1, 13/26855-2)
DA SILVA, EMANUELI DO NASCIMENTO; AURELI, FEDERICA; D'AMATO, MARILENA; RAGGI, ANDREA; CADORE, SOLANGE; CUBADDA, FRANCESCO. Selenium Bioaccessibility and Speciation in Selenium-Enriched Lettuce: Investigation of the Selenocompounds Liberated after in Vitro Simulated Human Digestion Using Two-Dimensional HPLC-ICP-MS. Journal of Agricultural and Food Chemistry, v. 65, n. 14, p. 3031-3038, . (12/15020-4, 14/15425-0, 13/26855-2)
DA SILVA, EMANUELI DO NASCIMENTO; CADORE, SOLANGE. Bioavailability Assessment of Copper, Iron, Manganese, Molybdenum, Selenium, and Zinc from Selenium-Enriched Lettuce. Journal of Food Science, v. 84, n. 10, p. 2840-2846, . (13/26855-2, 12/15020-4, 14/15425-0, 16/23625-4, 08/57808-1)
DA SILVA, EMANUELI DO NASCIMENTO; HEERDT, GABRIEL; CIDADE, MIRLA; PEREIRA, CATARINIE DINIZ; MORGON, NELSON HENRIQUE; CADORE, SOLANGE. Use of in vitro digestion method and theoretical calculations to evaluate the bioaccessibility of Al, Cd, Fe and Zn in lettuce and cole by inductively coupled plasma mass spectrometry. Microchemical Journal, v. 119, p. 152-158, . (12/15020-4, 08/57808-1, 13/26855-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Emanueli Do Nascimento da. Nutrients and toxic elements in lettuce (Lactuca sativa): studies of bioaccessibility, bioavailability, biofortification and speciation. 2016. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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