New application of organozinc reagents in the synthesis of bioactive substances

Abstract

Organometallic Zinc bases complexed with lithium chloride derived from 2,2,6,6-tetramethylpiperidine (TMPH) were recently introduced in the literature and showed great potential in the functionalization of several aromatic rings and heterocyclic. However, their reactivity towards important substrates has not yet been properly studied. This is the case of isoquinoline and its derivatives that have so far received little attention from researchers working in the area. Thus, one objective of this project is to develop a methodology that allows the preparation of functionalized isoquinolines and can be applied to the synthesis of bioactive molecules. Moreover, in order to develop methodologies that can be applied in large scale reaction, we plan to study the solubility and reactivity of some zinc bases prepared from other amines, for example, from 2,6-dimethylpiperidine, which is much cheaper than TMPH. Besides the development of methodologies, the project may also contribute to the synthesis of some bioactive molecules that have been studied in the laboratory as meclonazepan an interesting benzodiazepine that has been used in the treatment of schistosomiasis.The proposals presented here are part of the project "Development of New Synthetic Methods Aiming at the Preparation of Bioactive Molecules", approved by FAPESP through the Young Researcher with the objective of nuclear research groups acting on modern themes and international integration.