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Bioprospection of solanaceous (Solanaceae) with fungitoxic activity against Moniliophthora perniciosa

Grant number: 12/02861-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2012
Effective date (End): July 31, 2015
Field of knowledge:Agronomical Sciences - Agronomy - Plant Health
Principal Investigator:Simone Possedente de Lira
Grantee:Flávio Rocha
Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil


Brazil had been ahead of the cocoa export market, but nowadays only occupies the sixth position. The main reason for the world Brazilian decline is attributed to the phytopathogen fungus Moniliophthora perniciosa, responsible for the disease of cacao, witches' broom. The present methods of this disease control are costly or have some risk to the ecosystem, which demand need to search for more alternatives. Earlier studies by our research group demonstrated the efficiency of a compound isolated from the leaves and fruits of Solanum Lycopersicum, with antifungal activity in vitro against M. perniciosa. The literature reports that different secondary metabolites of Solanaceae have antifungal activity. Since Brazil has the greatest biodiversity of plants on the planet, it is also considered as a promising source in the search for compounds that show some bioactivity of agronomic interest, an area little explored by the scientific community. Therefore, this study aims to explore the biological potential and chemical of secondary metabolites produced by plants of the Solanaceae family that have antifungal activity against M. perniciosa. For this, solanaceous species that, after the collection in the field, will be selected, will have their extracts and / or pure fractions obtained from leaves, and biologically evaluated their antifungal activity, it will be also chemically analyzed.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARCIANO CORREA, JOZE APARECIDA; FORTKAMP, DIANA; DA SILVA, CAMILA FURTUNATO; ROCHA, FLAVIO; GOMES, LUIZ HUMBERTO; RONCATO DUARTE, KEILA MARIA; FERREIRA, ANTONIO GILBERTO; DE LIRA, SIMONE POSSEDENTE. Biological activity of 7 beta-acetoxywithanolide D isolated from Acnistus arborescens. SEMINA-CIENCIAS AGRARIAS, v. 39, n. 6, p. 2835-2841, . (12/02861-0, 13/50228-8, 14/15760-3, 11/09349-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ROCHA, Flávio. Bioprospection of Solanaceae plants with fungitoxic activity against Moniliophthora perniciosa. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Escola Superior de Agricultura Luiz de Queiroz (ESALA/BC) Piracicaba.

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