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Grant number: 11/18785-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2012
Effective date (End): May 31, 2015
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Rodrigo Alvaro Brandão Lopes Martins
Grantee:Shaiane da Silva Tomazoni
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Osteoarthritis (OA) is a disease that commonly affects humans and is characterized as a degenerative process that covers the joints. OA affects the articular cartilage, subchondral bone, ligaments, joint capsule, synovial membrane and periarticular muscles. The treatment for this disorder is based on pharmacological therapy, surgical and non-pharmacological, alone or in combination, to maximize the beneficial effects and minimize side effects. This research project aims to evaluate and compare the effects of pharmacological therapy with nonsteroidal anti-inflammatory drug (NSAID) for topical use, the effects of physical activity and finally to the low power laser therapy (LBP) in an experimental model osteoarthritis. The OA will be induced by an injection of intra-articular papain in the right knee of male Wistar rats. After 21 days the animals will be treated with topical NSAID and / or physical activity (swimming) and / or LBP. Treatments will be performed 03 times per week for 08 weeks, a total of 24 sessions for swimming and for LBP. The application of topical diclofenac is also carried out, 03 times a week. Will be conducted morphological and biochemical analysis of the knee joint, including radiography, histology, total leukocytes, differentiated activity of myeloperoxidase (MPO), RT-PCR (COX-1, COX-2, IL-1², IL-6 , IL-10, TNF-±, MMP-3 and MMP-13) analysis of cytokines by ELISA (TNF-±, IL-1², IL-6 and IL-10), prostaglandin E2 (PGE2) and finally , Western-Blott (COX-1 and COX-2).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TOMAZONI, SHAIANE SILVA; PINTO LEAL-JUNIOR, ERNESTO CESAR; FRIGO, LUCIO; PALLOTTA, RODNEY CAPP; TEIXEIRA, SIMONE; DE ALMEIDA, PATRICIA; BJORDAL, JAN MAGNUS; BRANDAO LOPES-MARTINS, RODRIGO ALVARO. Isolated and combined effects of photobiomodulation therapy, topical nonsteroidal anti-inflammatory drugs, and physical activity in the treatment of osteoarthritis induced by papain. Journal of Biomedical Optics, v. 21, n. 10, . (11/18785-9)
TOMAZONI, SHAIANE SILVA; PINTO LEAL-JUNIOR, ERNESTO CESAR; PALLOTTA, RODNEY CAPP; TEIXEIRA, SIMONE; DE ALMEIDA, PATRICIA; BRANDAO LOPES-MARTINS, RODRIGO ALVARO. Effects of photobiomodulation therapy, pharmacological therapy, and physical exercise as single and/or combined treatment on the inflammatory response induced by experimental osteoarthritis. Lasers in Medical Science, v. 32, n. 1, p. 101-108, . (11/18785-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
TOMAZONI, Shaiane da Silva. Effects of low-level laser therapy, topical non-steroidal antiinflammatory drug and physical activity on papain-induced osteoarthiritis.. 2015. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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