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Investigation of the effects of new thiazolidinediones in animal model of metabolic syndrome.

Grant number: 12/14360-6
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2012
Effective date (End): January 31, 2015
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Dulcineia Saes Parra Abdalla
Grantee:Jacqueline Cavalcante Silva
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):13/23140-2 - Immunomodulation and angiogenic activity of new thiazolidine compounds in wound healing process on MKR mice, BE.EP.MS


This project aims to investigate the effects of new thiazolidinediones (TZDs) chemically modified in an animal model of metabolic syndrome and to compare the effects obtained with rosiglitazone, a TZD previously studied and established commercially. This assessment will cover the effects of thiazolidinediones on the expression of modified pro-inflammatory genes, anti-inflammatory liver and adipose tissue infiltration of macrophages in the liver and adipose tissue and the effect on gene expression and genes involved in adipokines insulin signaling in mice with metabolic syndrome developed.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, JACQUELINE C.; CESAR, FERNANDA A.; DE OLIVEIRA, EDSON M.; TURATO, WALTER M.; TRIPODI, GUSTAVO L.; CASTILHO, GABRIELA; MACHADO-LIMA, ADRIANA; DE LAS HERAS, BEATRIZ; BOSCA, LISARDO; RABELLO, MARCELO M.; et al. New PPAR gamma partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr-/- mice. PHARMACOLOGICAL RESEARCH, v. 104, p. 49-60, . (12/14360-6, 12/51316-5)
SILVA, JACQUELINE C.; DE OLIVEIR, EDSON M.; TURATO, WALTER M.; TROSSINI, GUSTAVO H. G.; MALTAROLLO, VINICIUS G.; PITTA, MARINA G. R.; PITTA, IVAN R.; DE LAS HERAS, BEATRIZ; BOSCA, LISARDO; RUDNICKI, MARTINA; et al. GQ-11: A new PPAR agonist improves obesity-induced metabolic alterations in LDLr-/- mice. International Journal of Obesity, v. 42, n. 5, p. 1062-1072, . (12/14360-6, 12/51316-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Jacqueline Cavalcante. Investigation of new thiazolidine compounds effects in animal model of metabolic syndrome. 2015. Master's Dissertation - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.

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