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Molecular Investigation of PTEN and DREAM Genes in Patients with Multi-nodular Goiter.

Grant number: 12/11479-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): January 01, 2013
Effective date (End): December 31, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Ericka Barbosa Trarbach
Grantee:Amanda Shinzato
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Multinodular goiter (MNG) is defined as an enlargement of the thyroid gland that is characterized by heterogeneity in growth and function of thyroid follicular cells. It is a benign and very common disease. Constitutive activation of the phosphatidylinositol 3-kinase (PI3K) signal transduction pathway, including PTEN loss of expression, in follicular cells has been frequently involved in the cancer and goiter development in Cowden syndrome. Recently, was demonstrated that over expression of DREAM (downstream regulatory element antagonist modulator) provokes a marked enlargement of the thyroid gland in transgenic mice. Additionally, increased levels of DREAM protein were observed in human multinodular goiters, suggesting a novel etiopathogenic mechanism in nodular development in humans. The purpose of this project is to investigate the role of germinative mutations in PTEN and DREAM genes in etiology of MNG. The DREAM expression was also evaluate in patients with MNG.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SHINZATO, Amanda. Molecular investigation of PTEN and DREAM genes in patients with multinodular goiter. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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