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Water sorption and solubility of temporary resilient materials for denture base relining after incorporation of antimicrobial agents

Grant number: 12/09902-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2012
Effective date (End): December 31, 2013
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Karin Hermana Neppelenbroek
Grantee:Janaina Gomes Maciel
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


The incorporation of antifungal agents/antimicrobials in temporary denture relines has proved to be a viable alternative for the treatment of denture stomatitis. This treatment has the advantage of breaking the re-infection of supporting tissue via denture-fitting surface as it eliminates the contact of the prosthetic biofilm with the infected tissues, by acting upon them through the incorporated drugs, which are released gradually over the clinical life of these materials. Previous studies demonstrated that up to 14 days, the antifungal nystatin and antimicrobial chlorhexidine diacetate added to temporary relines (Trusoft e Softone) were the drugs that showed the minimum inhibitory concentrations (MICs) for biofilm of C. Albicans. Furthermore, it was observed that the addition of these drugs did not result in deleterious effects on the Shore A hardness, surface roughness, and tensile strength of the materials. Despite of these favorable results, information about the effects of the addition of antimicrobial agents in its MCIs on other properties of the resilient relines is lacking. This present study will evaluate the effect of the addition of the MICs of antimicrobial agents used for denture stomatitis' treatment upon water sorption and solubility of temporary resilient lining materials. To calculate the water sorption values and solubility, specimens (50 mm X 0,5 mm) will be dried, immersed in water for 24 h, 7 e 14 days, weighed, dried, and weighed again. The experimental results will be compared with the controls and the data analyzed statistically (alfa= 5%).(AU)

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