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Nutritional status of pregnant women with sickle cell anemia and its association with obstetric complications and perinatal outcome

Grant number: 12/03547-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2012
Effective date (End): September 30, 2015
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Roseli Mieko Yamamoto Nomura
Grantee:Letícia Vieira de Paiva
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The prognosis of pregnancy is influenced by maternal nutritional status before and during pregnancy. It is known that, since childhood, people with sickle cell disease have poor growth. In women with this disease, impaired nutritional status may influence maternal and perinatal outcomes. Studies on body composition in children with sickle cell anemia show impaired deposits of fat (energy) and protein, suggesting that the nutritional needs are not met. The same should occur during pregnancy, and these aspects have not been investigated in pregnancy. Our goal is to analyze the nutritional status of pregnant women with sickle cell disease, evaluating the maternal dietary intake, since the beginning of prenatal care and performing follow-up until delivery. Will investigate the association between the parameters of nutritional assessment and adverse outcomes, maternal and perinatal outcomes. Methods: Will be evaluated 40 pregnant women with sickle cell disease from the onset of pre-natal specialist. Will be carried out anthropometric measurements and body mass index. Pregnant women will be interviewed for the analysis of dietary intake by food frequency questionnaire, which will characterize and total energy intake and intake of macronutrients (carbohydrates, proteins and lipids) and micronutrients (Calcium, Iron, Folate, Zinc, Vitamins A, E, and C. It will be held prenatal nutrition quarterly review monthly. will be investigated following obstetric and perinatal variables: occurrence of obstetric complications or other maternal diseases, gestational age, mode of delivery, indication of cesarean section, previous RBC indices, intra and postoperatively, need for transfusion of blood products, length of stay, complications in the puerperium (transfusion, infection, dehiscence), weight of newborn weight rating (suitable, small or large for gestational age), sex of the newborn, Apgar scores, perinatal death, other perinatal complications, umbilical cord pH. be adopted as the significance level of 0.05 (alpha = 5%). Thus, descriptive levels (p) below this value are considered significant (p <0.05).

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LETICIA VIEIRA PAIVA; ANA MARIA KONDO IGAI; ROSELI MIEKO YAMAMOTO NOMURA. Maternal malnutrition during pregnancy among women with sickle cell disease. Revista da Associação Médica Brasileira, v. 69, n. 12, . (12/03547-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PAIVA, Letícia Vieira de. Nutrition of pregnant women with sickle cell anemia, maternal complications and perinatal outcomes. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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