Nutritional status of pregnant women with sickle cell anemia and its association with obstetric complications and perinatal outcome

Abstract

The prognosis of pregnancy is influenced by maternal nutritional status before and during pregnancy. It is known that, since childhood, people with sickle cell disease have poor growth. In women with this disease, impaired nutritional status may influence maternal and perinatal outcomes. Studies on body composition in children with sickle cell anemia show impaired deposits of fat (energy) and protein, suggesting that the nutritional needs are not met. The same should occur during pregnancy, and these aspects have not been investigated in pregnancy. Our goal is to analyze the nutritional status of pregnant women with sickle cell disease, evaluating the maternal dietary intake, since the beginning of prenatal care and performing follow-up until delivery. Will investigate the association between the parameters of nutritional assessment and adverse outcomes, maternal and perinatal outcomes. Methods: Will be evaluated 40 pregnant women with sickle cell disease from the onset of pre-natal specialist. Will be carried out anthropometric measurements and body mass index. Pregnant women will be interviewed for the analysis of dietary intake by food frequency questionnaire, which will characterize and total energy intake and intake of macronutrients (carbohydrates, proteins and lipids) and micronutrients (Calcium, Iron, Folate, Zinc, Vitamins A, E, and C. It will be held prenatal nutrition quarterly review monthly. will be investigated following obstetric and perinatal variables: occurrence of obstetric complications or other maternal diseases, gestational age, mode of delivery, indication of cesarean section, previous RBC indices, intra and postoperatively, need for transfusion of blood products, length of stay, complications in the puerperium (transfusion, infection, dehiscence), weight of newborn weight rating (suitable, small or large for gestational age), sex of the newborn, Apgar scores, perinatal death, other perinatal complications, umbilical cord pH. be adopted as the significance level of 0.05 (alpha = 5%). Thus, descriptive levels (p) below this value are considered significant (p <0.05).