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Influence of estrogens, progestins and androgens on ADAMTS-1 levels and distribution in normal and tumoral breast cells

Grant number: 12/10053-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): August 01, 2012
Effective date (End): July 31, 2014
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Vanessa Morais Freitas
Grantee:Suély Vieira da Silva
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:10/07699-1 - Protease ADAMTS1 influencing breast cancer behavior and microenvironment , AP.JP


Breast cancer is the most incident neoplasia among women. In Brazil this type of câncer is the leading cause of death among women. Breast tumor microenvironment is enriched by a variety of factors, which together promote the development and progression. The malignant transformation of mammary cell activity involves changes in different genes and proteins, which results in uncontrolled cell cycle and changes on cell differentiation. Sex hormones are among many factors that induce and promote carcinogenesis. Alterations in hormone secretion result in imbalance of tissue homeostasis, leading to several changes of the environment, which may favor the appearance of cancer. Recent studies show that there are variations in the levels of ADAMTS-1 in tumor tissues compared to normal tissues, but the exact role of this protease and the mechanism involved remains to be elucidated. Previous results from our group show that estrogen, progesterone and testosterone are able to inhibit or promote the expression of mRNA ADAMTS-1 in normal and tumoral breast cells. In this project, we are going to study the effect of these hormones alone or in combination, and at different concentrations to evaluate the protein levels and subcellular distribution of ADAMTS-1.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, SUELY V.; LIMA, MAIRA A.; CELLA, NATHALIE; JAEGER, RUY G.; FREITAS, VANESSA M.. ADAMTS-1 Is Found in the Nuclei of Normal and Tumoral Breast Cells. PLoS One, v. 11, n. 10, . (13/01092-6, 15/02498-1, 15/09845-9, 12/10053-1, 10/07699-1, 15/19773-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Suély Vieira da. Influence of estrogen, progesterone and testosterone on ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) levels and distribution in normal and tumoral breast cells.. 2014. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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