Scholarship 12/09882-3 - Blastocladiella emersonii, Germinação - BV FAPESP
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Phosphoproteomic analysis of the aquatic fungus Blastocladiella emersonii during two cell differentiation stages: germination and sporulation.

Grant number: 12/09882-3
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Start date until: August 01, 2012
End date until: January 31, 2015
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Suely Lopes Gomes
Grantee:Juliana Crestani
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):13/13762-6 - Proteomic and phosphoproteomic analysis of Blastocladiella emersonii during the germination and sporulation stages of the fungus, BE.EP.PD

Abstract

The aquatic fungus Blastocladiella emersonii presents an interesting life cycle, which has drastic biochemical and morphological changes during two cell differentiation stages: germination and sporulation. In germination, for example, protein synthesis is inhibited, a transient increase of cAMP levels is observed, activation of PKA is detected, as well as mobilization of cellular glycogen and an efflux of calcium. In addition, in sporulation, which is induced under starvation conditions, the presence of calcium and calmodulin are necessary to start this phase. Altogether these results suggest a possible phosphorylation/dephosphorylation control, probably through cell signaling networks during the development of B. emersonii. Therefore, the present work aims to elucidate these signaling mechanisms by using a phosphoproteomic analysis of B. emersonii during the germination and the sporulation. The results of this work will contribute to improve the knowledge of the cellular regulatory processes of this model.

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