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The role of IL-33 in the progression of periapical lesion in experimental model

Grant number: 12/08993-6
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): July 01, 2012
Effective date (End): June 30, 2014
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Sandra Yasuyo Fukada Alves
Grantee:Letícia Andreotti Bignardi
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Osteoimmunology is an emerging field of research dedicated to study the relationship between the skeletal and immune system. It has been shown that diverse mediators released during an inflammatory process can also modulate development and function of osteoclasts and osteoblasts, which are the cells responsible for the bone degradation and formation. The balance between both cells activity will determine the extension of bone resorption or formation. Bone and tooth resorption in patients with chronic inflammatory disease like periodontitis are the main complication and that can finally lead to tooth loss. The scientific literature has described new cytokine and, their role in inflammatory response has also been very studied and described. One cytokine member of IL-1 family, named IL-33, has a role in osteoclastogenesis. In vitro experiments have shown that IL-33 can inhibit osteoclasts differentiation and its mechanism. The role of IL-33 in the periapical lesion development and consequent bone metabolism has not been addressed yet. Thus, the aim of the present study is to investigate, how IL-33 participates in the inflammatory process during the periapical lesion formation and if IL-33 modulates the bone metabolism in vivo. The findings of the present study will give rise to a better understanding of the mechanisms of IL-33 underlying osteoclastogenesis and bone resorption during periapical lesion, as well as provide knowledge that can help the development of alternative therapeutic target for its treatment.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BIGNARDI, Letícia Andreotti. Study of the role of the IL-33/ST2 axis in experimental periapical lesion induced in mice. 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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