Advanced search
Start date
Betweenand
Related content

Morita-Baylis-Hillman in medicinal chemistry: design, synthesis and biological evaluation of potential antifungal agents

Grant number: 12/08048-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2012
Effective date (End): February 26, 2017
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Fernando Antonio Santos Coelho
Grantee:Marília Simão dos Santos
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

This PhD project has as goal the design, synthesis and biological evaluation of new substances with potential antifungal activity, using Morita-Baylis-Hillman adducts as substrate. These new substances were planned based on the models, available in the literature, for the prediction of antifungal activity. By using a new synthetic strategy we intend to prepared new substances to be tested against a panel of fungi strains. The results of this evaluation should allow the discovery of hits that it will be used as lead compounds for new antifungal agents. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
More itemsLess items
Articles published in other media outlets ( ):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, MARILIA S.; COELHO, FERNANDO; LIMA-JUNIOR, CLAUDIO G.; VASCONCELLOS, MARIO L. A. A.. The Morita-Baylis-Hillman Reaction: Advances and Contributions from Brazilian Chemistry. CURRENT ORGANIC SYNTHESIS, v. 12, n. 6, p. 830-852, . (13/10449-5, 12/08048-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Marília Simão dos. Design, synthesis and biological evaluation of new nitrogen compounds. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

Please report errors in scientific publications list using this form.

Filed patent(s) as a result of this research project

COMPOSTO COM ATIVIDADE ANTIFÚNGICA, PROCESSO DE SÍNTESE DO COMPOSTO, E USO DO COMPOSTO BR1020170180131 - Universidade Estadual de Campinas (UNICAMP) . Marilia Simão Dos Santos ; Fernando Antônio Santos Coelho ; Angélica Zaninelli Schreiber ; Luzia Lyra Fernandes ; João Ernesto De Carvalho ; Ana Lucia Tasca Gois Ruiz - August 2017, 23