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Maternal high fat diet: influences on maternal behavior and offspring development

Grant number: 12/07378-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2012
Effective date (End): May 31, 2016
Field of knowledge:Biological Sciences - Pharmacology
Principal researcher:Luciano Freitas Felicio
Grantee:Marianne Orlandini Klein
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):14/06980-0 - Maternal high fat diet effects on neuronal fate of arcuate nucleus during development, BE.EP.DR


In 2008, data from WHO showed that 1.5 billion of people were overweight. Recent research conducted by Ministry of Health revealed that 49% of Brazilians are overweight. Therefore, obesity became a big problem of public health. There are evidence that maternal food consumption can cause impairment in adult life of the offspring, like a high risk of developing obesity and metabolic alterations. Furthermore, mother's high fat diet seems to be able of making changes in methylation and expression of opioid-related genes of descendents. However, few studies have been investigating the influence of maternal high fat diet on maternal behavior and perinatal development of the young. The influence of a high fat diet on opioid system is poorly understood too. This study aims to investigate the influence of high fat diet in the reproduction context, focusing on mother-pups interaction and its immediate and late effects. For this, female rats will be divided randomly in to groups: HF group that will be feed with high fat diet (45% of fat) from day 0 of pregnancy to 21th day of lactation (PND21); and control group that will receive a pattern diet. In PDN21, each litter will be subdivided in 2 groups: one that will continue receiving the same diet of the mother, and another one that will receive a different diet of the mother resulting in 4 different experimental groups: (C-C control-control; C-HF control-high fat; HF-C high fat; HF-HF high fat-high fat). It will be evaluated the glucose levels of the mother, and the glucose and insulin tolerance tests will be realized with her. In PND5 and 10, it will be evaluated the maternal behavior with and without previous manipulation. In PND21, mothers will be sacrificed and their brain will be removed for analyses of the expression of opioid receptors genes in hypothalamus. The physical development of the offspring will be evaluated, and the maternal behavior of female will be analyzed in adult life.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KLEIN, MARIANNE ORLANDINI; MACKAY, HARRY; EDWARDS, ALEXANDER; PARK, SU-BIN; INHASZ KISS, ANA CAROLINA; FELICIO, LUCIANO FREITAS; ABIZAID, ALFONSO. POMC and NPY mRNA expression during development is increased in rat offspring brain from mothers fed with a high fat diet. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, v. 64, n. SI, p. 14-20, . (14/06980-0, 12/07378-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
KLEIN, Marianne Orlandini. Maternal high fat diet: influences on maternal behavior and offspring development.. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.

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