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Language assessment in temporal lobe epilepsy: correlations with structural and functional neuroimage.

Grant number: 12/05364-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2012
Effective date (End): January 31, 2017
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Fernando Cendes
Grantee:Tátila Martins Lopes
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Patients with mesial temporal lobe epilepsy (MTLE) have hippocampal sclerosis with consequent deficit in episodic memory and also difficulties related to language, especially the naming and atypical lateralization for language suggesting the involvement of the mesial temporal lobe in this cognitive function. However, the mechanisms associated with this deficit are poorly known, because the mesial temporal region is anatomically distant from the areas responsible for language. Therefore, the aim of this study is to investigate the language, in addition to episodic memory and executive function in patients with MTLE, correlating these data with structural and functional neuroimaging. In order to we will include 20 subjects in each group: with unilateral hippocampal atrophy (right or left) and bilateral, without hippocampal atrophy; refractory to drug treatment, with good response to drug treatment and control subjects. All will undergo cognitive assessment, through the Edinburgh handedness test, Boston naming test, test and categorical phonemic verbal fluency, verbal and visual pairs associated with the Wechsler Memory Scale-Revised, Rey auditory verbal learning test, trail making-A and B and the Stroop test and also will undergo magnetic resonance imaging for structural and functional. Data will be analyzed using statistical software SYSTAT 9 and statistical parametric mapping (SPM 8) depending on the type of variable for comparisons of cognitive performance and neuroimaging between groups, and correlations between cognitive and neuroimaging using appropriate statistical tests for each analysis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOPES, TATILA MARTINS; DE CAMPOS, BRUNNO MACHADO; ZANAO, TAMIRES ARAUJO; BALTHAZAR, MARCIO L. F.; YASUDA, CLARISSA LIN; CENDES, FERNANDO. Hippocampal atrophy disrupts the language network but not hemispheric language lateralization. Epilepsia, v. 60, n. 4, p. 744-755, . (13/07559-3, 12/05364-8)
LOPES, TATILA MARTINS; YASUDA, CLARISSA LIN; DE CAMPOS, BRUNNO MACHADO; BALTHAZAR, MARCIO L. F.; BINDER, JEFFREY R.; CENDES, FERNANDO. Effects of task complexity on activation of language areas in a semantic decision fMRI protocol. Neuropsychologia, v. 81, p. 140-148, . (12/05364-8, 13/07559-3)
ALVIM, MARINA K. M.; MORITA, MARCIA E.; YASUDA, CLARISSA L.; DAMASCENO, BENITO P.; LOPES, TATILA M.; COAN, ANA CAROLINA; GHIZONI, ENRICO; TEDESCHI, HELDER; CENDES, FERNANDO. Is inpatient ictal video-electroencephalographic monitoring mandatory in mesial temporal lobe epilepsy with unilateral hippocampal sclerosis? A prospective study. Epilepsia, v. 59, n. 2, p. 410-419, . (12/05364-8, 15/17066-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LOPES, Tátila Martins. Language assessment in mesial temporal lobe epilepsy: correlations with structural and functional neuroimaging. 2017. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.

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