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Effects of ascorbic acid on the corneal endothelium and on tumor necrosis factor-alpha (tnf-±) in dogs undergoing phacoemulcification

Grant number: 11/20041-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2012
Effective date (End): February 28, 2015
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:José Luiz Laus
Grantee:Ivan Ricardo Martinez Padua
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


Cataract is one of the most common ocular diseases in dogs. Phacoemulsification is the most acceptable treatment therapy and the most cataract surgery routinely performed among ophthalmologists. Shortened surgical time, smaller incision size e minimal trauma are among the advantages of phacoemulsification. Uveitis, glaucoma, retinal detachment and corneal alteration due to endothelial damage are possible complications. Endothelial cellularity is an important factor to be considered for the surgical success, since endothelial cell damage may induce permanent corneal decompensation. High energy vibration of the ultrasonic tip and free radicals release may be traumatic to the corneal endothelial and cause decompensation. This research will evaluate the role of ascorbic acid on endothelial protection in dogs submitted to cataract surgery. Non-contact specular microscopy and the analysis of tumor necrosis factor alpha (TNF-±) in the aqueous humor will be performed.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PADUA, IVAN R. M.; VALDETARO, GISELE P.; LIMA, TIAGO B.; KOBASHIGAWA, KARINA K.; SILVA, PALOMA E. S.; ALDROVANI, MARCELA; PADUA, PEDRO P. M.; LAUS, JOSE L.. Effects of intracameral ascorbic acid on the corneal endothelium of dogs undergoing phacoemulsification. VETERINARY OPHTHALMOLOGY, v. 21, n. 2, p. 151-159, . (11/20041-8)
PADUA, I. R. M.; RIBEIRO, A. P.; PADUA, P. P. M.; GUIMARAES, P. J.; SILVA, M. L.; PISO, D. Y. T.; MARTINS, B.; ALDROVANI, M.; SEMOLIN, L. M. S.; CAMACHO, A. A.; et al. Efeitos do maleato de timolol, do levobunolol e da apraclonidina sobre a pressão intraocular, o diâmetro pupilar, a pressão sanguínea e a frequência cardíaca, em cães da raça Beagle. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 68, n. 3, p. 641-650, . (11/20041-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PADUA, Ivan Ricardo Martinez. Efeitos do ácido ascórbico intracameral sobre o endotélio corneal e sobre o fator de necrose tumoral alfa (TNF-a) em cães submetidos à facoemulsificação. 2015. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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