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Would antidepressant treatment in rats with aortic regurgitation modify central gene expression of oxytocin and vasopressin?

Grant number: 12/06279-4
Support Opportunities:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): July 01, 2012
Effective date (End): August 31, 2012
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Juliana Irani Fratucci de Gobbi
Grantee:Ana Carolina Mieko Omoto
Supervisor: Alan Kim Johnson
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Research place: University of Iowa, United States  
Associated to the scholarship:11/23513-8 - Would antidepressant treatment in rats with aortic regurgitation modify central gene expression of oxytocin and vasopressin?, BP.IC


Aortic regurgitation (AR) leads to a left ventricle dilation and hypertrophy in response to a chronic volume overload. It is still very frequent in developing countries, for instance Brazil, and often as secondary to rheumatic fever. Usually, chronic AR is generally well tolerated for many years, when with the heart dilated the patient search for treatment. Bidirectional association with depression and cardiovascular disease has been described. Selective serotonin reuptake inhibitors (SSRI) are widely prescribed to treat several affective disorders, especially for cardiovascular patients since they decrease arrhythmia probability. These SSRI improves cardiac function in rats submitted to stress protocols. Preliminary study from our laboratory showed that following 4 weeks of treatment with one SSRI (paroxetin) in subcrhonic AR rats there was a decreased in daily sodium intake and an improvement in systolic function. An increase in the central oxytocinergic transmission may be involved in this peripheral improvement to the heart. The investigation about the mechanisms underlying this improvement are necessary. Therefore the aims of this project is investigate the effects of 4 weeks of treatment of paroxetin, a SSRI, in rats with a subchronic AR over the central central gene expression of oxytocin and vasopressin using a reverse transcription polymerase chain reaction (RT-PCR). (AU)

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