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Characterization of the neurophatic antinociceptive activity of bioactive molecules

Grant number: 12/03652-6
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): June 01, 2012
Effective date (End): May 31, 2013
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Principal Investigator:Mary Ann Foglio
Grantee:Humberto Moreira Spindola
Supervisor: Zaijie Jim Wang
Host Institution: Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas (CPQBA). Universidade Estadual de Campinas (UNICAMP). Paulínia , SP, Brazil
Research place: University of Illinois at Chicago (UIC), United States  
Associated to the scholarship:10/09287-2 - Characterization of antinociceptive activity of bioactive molecules: preclinical studies for the development of new analgesics., BP.PD

Abstract

As a part of the ongoing studies, this stage of the work involves carring out experimental models to the evaluation of the pharmacological activities attributed to the vouacapans derivatives obtained from Pterodon genus 6a-oxovouacapan-7²-17b-lactone e 6a-hidroxivouacapan-7²-17b-lactone, and harmicine, a ²-carboline obtained from Peganum genus, against nervous system disorders culminating with the appearance of neuropathic pain. This type of noxious stimulus is among the most difficult to diagnose and treat, because is not always possible to identify the causative agent, so it is necessary the research of new drugs capable of blocking neuropathic mediation, in order to control adequately the chronic pain arisen from this process. Aiming to learn new techniques for the study of neuropathic pain, we established collaboration with prof. Dr. Z. Jim Wang, from the College of Pharmacy at the University of Illinois at Chicago (UIC). This opportunity will work with experimental models that are closer to the clinical responses that will address the treatment of chronic neuropathic pain. It will be evaluated different neuropathic stimuli throughout rodent models: central mediation, with the excitotoxic spinal cord injury model (neuromodulators intraspinally injected); peripheral mediation with neuroma model (phantom limb pain), chronic constriction injury model (muscular compression) and the partial sciatic nerve ligation model (burning pain - causalgia). Still, the quantification of mieloperoxidase (MPO) activity enzyme related to the chronic inflammatory process. These results will permit us to demonstrate the compounds´ potential to be used on this kind of pain, which increasingly affects the worldwide population, lacking more effective and least toxic agents. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SPINDOLA, HUMBERTO M.; GRANDO, ROGERIO; FIGUEIREDO, MARIANA C.; BASTING, ROSANA; QUEIROZ, N. C. A.; DE FATIMA, ANGELO; DE CARVALHO, JOAO E.; WANG, ZAIJIE J.; FOGLIO, M. A.. Derivatives of furanditerpenes from Pterodon genus: Pharmacological studies disclose their potential as chronic pain relief in mice. European Journal of Pharmacology, v. 804, p. 68-77, . (10/09287-2, 12/19661-4, 12/03652-6)

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Filed patent(s) as a result of this research project

COMPOSIÇÃO FARMACÊUTICA À BASE DE EXTRATO DICLOROMETANO DE PTERODON PUBESCENS BENTH., SUA COMBINAÇÃO SINÉRGICA, FORMULAÇÃO E USO. BR1320180763783 - Universidade Estadual de Campinas (UNICAMP) . ROSANNA TARKANY BASTING / MARY ANN FOGLIO / JOÃO ERNESTO DE CARVALHO / ROGÉRIO GRANDO / HUMBERTO MOREIRA SPINDOLA / MARIANA CECCHETTO FIGUEIREDO / KARIN MAIA MONTEIRO / ILZA MARIA DE OLIVEIRA SOUSA / VANESSA HELENA DA SILVA SOUZA / NUBIA DE CASSIA ALMEIDA QUEIROZ / MICHELLE PEDROSA JORGE - December 2018, 18