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Glutathione S-transferase polymorfisms (GSTM1, GSTT1 e GSTP1) as modulation factors in Sickle Cell Disease phenotype

Grant number: 12/02171-4
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Claudia Regina Bonini Domingos
Grantee:Willian Marcel Barberino
Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil


Sickle Cell Anemia (SCA) is a hereditary hemolytic disease which causes complex and several clinical manifestations. The oxidative stress is one of the factors that influence the phenotype of the carrier and the processes of vascular occlusion by increasing the adhesive properties of erythrocytes, leukocytes and platelets to the endothelium. During the transformation of the erythrocyte with S hemoglobin in sickle erythrocyte among the biochemical events there is the oxidative degradation of this hemoglobin releasing degradation products, Fe 2+ and Fe 3+ complexes that attack the cell membrane resulting in lipid hydroperoxides and peroxyl and alkoxyl radicals. Among the phase II detoxifying enzymes the most studied are GSTs (GSTM1, GSTT1 and GSTP1) that may provide low enzymatic activity, affecting the body's antioxidant defenses. Considering the high incidence of AF in our country and the several clinical manifestations in patients, this study aims to investigate polymorphisms of GSTs (GSTT1, GSTM1 and GSTP1) and determine its influence on oxidative parameters - lipid peroxidation by MDA and DNA damage by micronucleus and comet in patients with AF.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BARBERINO, Willian Marcel. Polimorfismos GSTM1, GSTT1 e GSTP1 da enzima Glutationa S-transferase como fatores moduladores do fenótipo na anemia falciforme. 2014. Master's Dissertation - Universidade Estadual Paulista (Unesp). Instituto de Biociências Letras e Ciências Exatas. São José do Rio Preto São José do Rio Preto.

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