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Strutured lipids obteined from intersterification of tributyrin and flax seed oil and their chemopreventive potential during promotion phase of experimental hepatocarcinogenesis

Grant number: 12/00498-6
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): June 01, 2012
Effective date (End): January 26, 2016
Field of knowledge:Health Sciences - Nutrition
Principal researcher:Fernando Salvador Moreno
Grantee:Juliana Festa Ortega
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The high incidence and mortality of hepatocellular carcinoma (HCC), as well as the limited treatment and poor prognosis of this disease make it important to adopt measures such as chemoprevention. Tributyrin (TB), a prodrug of butyric acid (BA) is a bioactive compound found in foods such as honey and milk. TB reduced the incidence and size of preneoplasic lesions and also induced apoptosis and histone acetylation when administered during the initiation and promotion or only during promotion phase of experimental hepatocarcinogenesis. However, its organoleptic characteristics and bioavailability limit the use of this substance as a chemopreventive agent. By an enzymatic reaction with specific 1,3 lipases, a mixture of TB and flax seed oil might increase the absorption and bioavailability of AB present in TB. Flaxseed oil is a natural source of ALA, and also has chemopreventive activity. The action of histone deacetylases inhibitors (HDAC), such as TB, has been related to changes in the methylation state of promoters. In this context, the objective of this project is to produce structured lipids by interesterification of TB with flax seed oil and to evaluate its chemopreventive activity in a model of hepatocarcinogenesis in rats. The expression of RASSF1A, NORE1A (RAASF5) and p21, as well as histone acetylation and alteration of DNA methylation, would elucidate the mechanisms and chemopreventive potential of the strutured lipids. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ORTEGA, Juliana Festa. Structured lipids obtained from intersterification of tributyrin and flax seed oil and their chemopreventive potential during early promotion phase of experimental hepatocarcinogenesis in rats. 2016. Doctoral Thesis - Universidade de São Paulo (USP). Conjunto das Químicas (IQ e FCF) (CQ/DBDCQ) São Paulo.

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