Exposure to solar ultraviolet radiation is responsible for inducing the formation of singlet oxygen and free radicals in the skin, which can cause damage to cellular macromolecules, leading to the skin cancer formation. According to the INCA (Cancer National Institute), the skin cancer is the most common type of cancer in Brazil, covering about 25% of all malignant tumors reported. Recent studies have shown that trans-resveratrol (RES), due to their antioxidant, anti-inflammatory and chemopreventive properties, is a potential active substance in the therapy against changes due to photoaging, especially in the action against skin cancer. However, the RES has low bioavailability in vivo, due to rapid metabolism when administered orally. Thus, its skin administration would be appropriate in order to locate it on their site of action. Although, some physical-chemical properties, such as limited aqueous solubility, hampering their topical therapy effectiveness, since it has low penetration in the skin. The solid lipid nanoparticles (SLN) have been successfully used in the pharmaceutical and cosmetic areas because they have the ability to compartmentalize, efficiently, several groups of active ingredients and modify their proprieties and behavior in biological environment. In this sense, SLN have been shown to be advantageous in topical administration of various substances mainly due to its characteristics of interaction with the stratum corneum and other layers of the skin and the ability of arrangement with a protective and sustainer effect of the release. In this project, we aimed to develop and characterize, under the physical-chemical aspect, SLN for the incorporation of RES. Thus, it is expected to develop a delivery system for the RES in nanostructural level that optimizes the use of RES as a depigmenting agent and in antitumor therapy of melanoma.
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