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Correlation between chromosomal aneuploidy in sperm and embryo implantation rate

Grant number: 12/07299-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2012
Effective date (End): December 31, 2012
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal researcher:Lucia Regina Martelli
Grantee:Viviane Paiva Santana
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The etiology of infertility is directly related to chromosomal abnormalities in germ cells. Among them, aneuploidy, which stand out as the most frequent chromosomal abnormalities of the human species, responsible for failures in embryo implantation, abortions, fetal deaths and live births with malformation syndromes, mental retardation and developmental delay. Men with normal somatic karyotype may have different percentages of aneuploidy sperm, which, after fertilization, produce abnormal embryos. The present study aims to correlate the frequency of chromosomal aneuploidy in sperm with embryo implantation rate in couples undergoing assisted reproduction techniques. The methodology includes conducting couples somatic karyotype (chromosome analysis by GTG banding) and molecular cytogenetic study (technical Fluorescent In Situ Hybridization) for detection of aneussomias of chromosomes 9, X and Y in male germ cells. The sample group will consist of 50 infertile couples (random sample), without defining etiology male or female, Service in Human Reproduction, Hospital das Clínicas, FMRP-USP. The rate of embryo implantation is determined by hormonal evaluation in maternal peripheral blood and subsequent confirmation ultrasound. (AU)

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